Calorie Restriction, Protein Supplementation and Metabolic Health

Conditions:Obesity Weight Loss, Osteoporosis, Orthopedic, Women's Studies
Therapuetic Areas:Endocrinology, Rheumatology, Orthopedics / Podiatry, Reproductive
Age Range:50 - 65
Start Date:January 2012
End Date:June 2017
Contact:Janet Winkelmann, CMA

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Calorie Restriction and Metabolic Health

The purpose of this study is to determine whether consuming additional protein during
calorie restriction induced weight loss has beneficial or harmful effects on multi-organ
(liver, muscle, adipose tissue) insulin sensitivity, colonocyte proliferation rates, the gut
microbiome, muscle mass and function, and bone mineral density in obese, postmenopausal

Inclusion Criteria:

- Obese with body mass index (BMI) between 30 and 50 kg/m2

- Postmenopausal

- Sedentary (i.e., less than 1.5 hours of exercise per week)

Exclusion Criteria:

- Individuals with diabetes and/or uncontrolled hypertension

- Individuals with hepatitis B and/or C

- Individuals who smoke

- Individuals with an allergy to whey protein
We found this trial at
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
Saint Louis, MO
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