Trial Evaluating Dovitinib Combined With Fulvestrant, in Postmenopausal Patients With HER2- and HR+ Breast Cancer
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 7/11/2015 |
| Start Date: | April 2012 |
| End Date: | October 2015 |
| Contact: | Novartis Pharmaceuticals |
| Phone: | 1-888-669-6682 |
A Multicenter, Randomized, Double Blind, Placebo Controlled, Phase II Trial Evaluating the Safety and Efficacy of Dovitinib Combined With Fulvestrant, in Postmenopausal Patients With HER2- and HR+ Breast Cancer That Have Evidence of Disease Progression on or After Prior Endocrine Therapy
This trial is designed to enroll postmenopausal patients with locally advanced or
metastatic, HER2- and HR+ breast cancer not amenable to curative treatment by surgery or
radiotherapy, and whose disease has progressed on or after prior endocrine therapy.
Patients must undergo molecular pre-screening prior to entry.
metastatic, HER2- and HR+ breast cancer not amenable to curative treatment by surgery or
radiotherapy, and whose disease has progressed on or after prior endocrine therapy.
Patients must undergo molecular pre-screening prior to entry.
Inclusion Criteria:
1. Postmenopausal women with HER2-, HR+ locally advanced or metastatic breast cancer
2. Progression on or after endocrine treatment
3. Measureable disease as per RECIST
4. ECOG 0, 1 or 2
Exclusion Criteria:
1. Evidence of CNS or leptomeningeal metastases
2. Previous treatment with fulvestrant
3. Previous chemotherapy for locally advanced or metastatic breast cancer
4. Cirrhosis or chronic active/persistent hepatitis
Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
29
sites
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
101 Dudley St
Providence, Rhode Island 02905
Providence, Rhode Island 02905
(401) 274-1100
Women and Infants Hospital of Rhode Island Women & Infants Hospital of Rhode Island, a...
Click here to add this to my saved trials
Click here to add this to my saved trials
Roanoke, Virginia 24014
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials