Repeated Challenge of Insufficient Sleep: Endothelial Effects

Age Range:25 - 55
Start Date:August 2011
End Date:September 2014

Use our guide to learn which trials are right for you!

Repeated Challenge of Insufficient Sleep: Effects on Endothelial Function

The 24-hour-a-day, 7-day a week, work-world arrived within our lifetimes, and is here to
stay. Americans are working more and more, frequently at multiple jobs. The pattern of short
sleep during the week followed by attempts to recover on the weekend is in common practice,
but we know little of the associated health risks. What is the cost in terms of increasing
known risk markers for cardiovascular disease, of repeated nights of insufficient sleep, and
is this cost compounded with repetition, without adequate recovery? Evidence is accumulating
to suggest that short sleep duration is linked to the development of metabolic and
inflammation-associated diseases, such as cardiovascular disease. Mechanisms involved in the
development of cardiovascular disease include impaired vascular function and inflammation.
The current proposal is designed to investigate the effects of repeated periods of short
nocturnal sleep duration in 4 cycles (each cycle consisting of 3 nights of 4 hours of sleep
opportunity per night), and each cycle of short sleep followed by a single night of recovery
sleep. Vascular reactivity will be assessed using brachial artery flow mediated dilation, and
microcirculatory vasodilation will be assessed using perfusion imaging techniques. The
dependence of IL-6 and sVCAM-1 as measured in peripheral circulation, on vascular function,
will also be investigated.

Due to work, family, social and community obligations, millions of Americans cut back on
sleep for several nights in a row before having an opportunity to catch up. When the
opportunity does arise, it may only be for a single night, before the cycle of insufficient
sleep repeats. This study investigated what happens to human biology when insufficient sleep
becomes chronic and opportunities for recovery sleep are intermittent. It also investigated
recovery sleep itself, and the biological processes involved in reversing the effects of an
accumulated sleep deficit due to insufficient sleep duration.

Inclusion Criteria:

- Healthy volunteers

- Regular sleep-wake schedule

Exclusion Criteria:

- Diseases or medical conditions, including sleep disorders

- Current smoking

- Pregnant or nursing

- Recent time zone travel or shift work

- Regular medication use

- High blood pressure
We found this trial at
330 Brookline Ave
Boston, Massachusetts 02215
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
Boston, MA
Click here to add this to my saved trials