Non Small Cell Lung Cancer Patients Treated With Erlotinib Six Months or Longer
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | October 2012 |
| End Date: | February 2015 |
Non-Small-Cell Lung Cancer Patients Treated With Erlotinib Six Months or Longer: Demographics, Treatment and Outcome Characteristics of Patient Cases in a Community-Based Setting
With roughly 80% of cancer patients receiving their oncology care in the community setting,
the investigators are proposing to sample from a community-based center to evaluate the
percentage of epidermal growth factor receptor (EGFR)-wild type patients that gain benefit
from erlotinib and assess the clinical characteristics that are associated with
erlotinib-responders. Additionally, biopsy specimens from enrolled patient cases that are
EGFR-wt will be evaluated via exploratory genetic analysis for correlated markers.
the investigators are proposing to sample from a community-based center to evaluate the
percentage of epidermal growth factor receptor (EGFR)-wild type patients that gain benefit
from erlotinib and assess the clinical characteristics that are associated with
erlotinib-responders. Additionally, biopsy specimens from enrolled patient cases that are
EGFR-wt will be evaluated via exploratory genetic analysis for correlated markers.
Inclusion Criteria:
- Patients must have had NSCLC.
- Patients must have received erlotinib (single-agent) for six months or longer for
NSCLC in the second/third line setting or as maintenance therapy.
- Patients must have tissue available for EGFR-mutation status testing (if not
previously performed) or EGFR-mutation status test results available.
- Patients must have tissue available for exploratory genetic analysis.
- Patients must have all clinical information, treatment response data and outcomes
data available for review.
- Patients must be deceased.
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