Shortened Aggrastat® Versus Integrilin in Percutaneous Coronary Intervention



Status:Recruiting
Conditions:Angina, Angina, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/17/2018
Start Date:April 2012
End Date:July 2019
Contact:Debbie Douglas, PhD
Email:ddouglas@medicure.com
Phone:204-594-3624

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A Randomized, Multicenter, Open-Label Study to Evaluate the Efficacy of Tirofiban Using a High-Dose Bolus Plus a Shortened Infusion Duration Versus Label-Dosing Eptifibatide in Patients Undergoing Percutaneous Coronary Intervention

The purpose this study is to assess whether a tirofiban regimen of a high-dose bolus plus a
shortened infusion duration compared to label-dosing eptifibatide in patients undergoing
percutaneous coronary intervention (PCI) is associated with a non-inferior composite rate of
death, PCI-related myocardial infarction, urgent target vessel revascularization or
in-hospital major bleeding within 48 hours following PCI or hospital discharge, whichever
comes first.


Inclusion Criteria:

- Age ≥18 years of age

- Scheduled to undergo PCI with an FDA, approved or cleared device (stent or procedures
such as balloon angioplasty, rotoblation, AngioSculpt, laser atherectomy,etc.) in one
or more native coronary target lesions

- Written informed consent

Exclusion Criteria:

- Primary PCI for STEMI as index procedure

- Prior STEMI within 48 hours before randomization

- Prior PCI within 30 days before randomization

- Planned staged PCI within the subsequent 24 hours after index PCI

- Use of abciximab within 7 days before randomization

- Use of tirofiban or eptifibatide within 12 hours before randomization

- Use of low-molecular weight heparin within 12 hours before randomization

- Use of bivalirudin within 12 hours before randomization
We found this trial at
13
sites
Gainesville, Georgia 30501
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550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Atlanta, GA
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1364 Clifton Rd NE
Atlanta, Georgia 30322
(404) 712-2000
Emory University Hospital As the largest health care system in Georgia and the only health...
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Atlanta, GA
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Doylestown, Pennsylvania 18901
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Doylestown, PA
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Kissimmee, Florida 34741
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Kissimmee, FL
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Nashville, Tennessee 37203
Principal Investigator: Brian K Jefferson, MD
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Nashville, TN
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New York, New York 10021
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New York, NY
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940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
Principal Investigator: Mazen Abu-Fadel, MD
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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Oklahoma City, OK
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Philadelphia, Pennsylvania
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Philadelphia, PA
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Richmond, Virginia 23225
Principal Investigator: Michael L Arcarese, MD
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Richmond, VA
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Rome, Georgia 30165
Principal Investigator: Hector R Picon, MD
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Rome, GA
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Saint Petersburg, Florida 33709
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Saint Petersburg, FL
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Thomasville, Georgia 31792
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Thomasville, GA
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