Mannitol - Potential Role in Hemodialysis Initiation for Reduction of Intra-dialytic Hypotension



Status:Completed
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:2/1/2019
Start Date:May 2012
End Date:December 2018

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Pilot Study of Intravenous Mannitol During Hemodialysis Initiation to Reduce the Occurrence of Intra-dialytic Hypotension.

Kidney failure can result from a variety of conditions and can be temporary or permanent.
Hemodialysis is available as a replacement treatment to perform the work that the kidneys
normally do. However, the dialysis procedure can be associated with rapid changes in the
composition of the blood - this may lead to changes in blood pressure and in turn reduced
blood supply to important parts of the body. We aim to investigate if giving a medicine
(called mannitol) during dialysis may be able to reduce the frequency of these low blood
pressure events.


Inclusion Criteria:

- Renal failure requiring intermittent hemodialysis initiation; adult patients aged over
18 years; written informed consent

Exclusion Criteria:

- Hyponatremia <130 mmol/L; acute myocardial infarction or stroke in previous 7 days;
cardiac transplant; ventricular arrhythmia; unstable angina; use of
pressors/midodrine; enrollment in conflicting research study; institutionalized
individuals; pregnancy; prisoners; documented allergy to mannitol
We found this trial at
1
site
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
2578
mi
from 91732
Boston, MA
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