Brain-imaging and Adolescent Neuroscience Consortium



Status:Not yet recruiting
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:Any
Updated:11/18/2012
Start Date:September 2012
End Date:September 2017
Contact:John R Knight, MD
Email:john.knight@childrens.harvard.edu
Phone:617-355-5433

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This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and
shorter-term effect of adolescent alcohol use on the developing brain.


The overall specific aims of this study are to: 1) assess the short and long-term
consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development
during preadolescence and adolescence; 2) determine the effects of timing, dose, and
duration of alcohol on brain and cognitive development; 3) assess recovery of neural and
behavioral function to determine if the plasticity of the adolescent brain makes it more or
less vulnerable to alcohol's acute and chronic effects; 4) understand how other key
covariates (e.g., existing or emerging psychopathology, family history of alcoholism,
demographics, pubertal development) factor into alcohol's effects on the brain; and 5)
identify early neural, cognitive, and affective markers that may predict alcohol abuse and
dependence during adolescence and/or adulthood.

Inclusion Criteria:

- able to read and understand English

- available for follow-up

- parental consent/adolescent assent for those 12-17 years

- consent for those 18-21 years

Exclusion Criteria:

- Weight > 300 lbs

- braces or unremovable embedded metal

- claustrophobia or inability to lie still in MRI machine

- current or past 12-mos pregnancy (females)

- requires urgent medical/mental health care
We found this trial at
4
sites
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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72 East Concord Street
Boston, Massachusetts 02118
(617) 638-5300
Boston University School of Medicine A leader in medical education and research, Boston University School...
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115 Mill St
Belmont, Massachusetts 02478
(617) 855-2000
McLean Hospital McLean Hospital is a comprehensive psychiatric hospital committed to providing easy access to...
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Cambridge, Massachusetts 02139
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