A Phase 2 Study of LY2495655 in Participants With Pancreatic Cancer



Status:Completed
Conditions:Cancer, Cancer, Pancreatic Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:6/22/2018
Start Date:December 2011
End Date:January 2016

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A Randomized Phase 2 Placebo-Controlled Study of LY2495655 in Patients With Advanced or Metastatic Pancreatic Cancer Receiving Chemotherapy

This phase 2 study is a multicenter, randomized, double-blind, placebo-controlled trial in
participants with locally advanced/inoperable or metastatic pancreatic cancer, and will
investigate 2 different doses of LY2495655 in combination with standard of care chemotherapy.


Inclusion:

- Unresectable or metastatic pancreas cancer; participants with previous radical surgery
for pancreas cancer are eligible after progression is documented

- Participants may have received previous adjuvant treatment with gemcitabine with or
without radiotherapy for pancreas cancer

- ECOG (Eastern Cooperative Oncology Group) Performance status ≤ 2

- Adequate organ function

- Have an estimated life expectancy of at least 12 weeks and in the judgment of the
investigator, will be able to complete at least 2 cycles of treatment

- Ability to perform the indicated functional performance measures at baseline

Exclusion:

- Prior systemic therapy for unresectable/metastatic pancreas cancer

- Any medical or psychiatric condition, orthopedic or neuromuscular conditions that
could limit participation or confound study results

- Currently taking medications that are considered both muscle building and performance
enhancing (for example, androgen therapies, or anabolic steroids)
We found this trial at
6
sites
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mi
from
The Woodlands, TX
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mi
from
Calgary,
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mi
from
Dallas, TX
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mi
from
Tyler, TX
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mi
from
Washington,
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mi
from
Wenatchee, WA
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