Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Insomnia Sleep Studies, Post-Surgical Pain, Neurology, Psychiatric |
| Therapuetic Areas: | Musculoskeletal, Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 11/30/2013 |
| Start Date: | February 2012 |
| Contact: | Daniel Yoo, MB |
| Email: | yood@hss.edu |
| Phone: | 646-797-8948 |
Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery
Pain, confusion, and breaks in normal sleep cycles have been challenges commonly faced by
patients after undergoing joint surgeries. To address these issues, melatonin, an
inexpensive over-the-counter supplement, has shown in previous to help manage sleep
disorders, prevent and treat post-operative confusion in patients over 70 years of age, and
reduce pain. The purpose of this study is to establish whether melatonin can aid in reducing
pain and post-operative confusion and improve sleep quality after total knee replacement
Inclusion Criteria:
- Patients 18-90 years old undergoing elective, primary total knee replacement
- American Society of Anesthesiologists (ASA) Physical Status I-III
- Epidural anesthesia/Patient Controlled Analgesia candidate
Exclusion Criteria:
- Mental impairment
- Pre-operative use of benzodiazepines, narcotics, or prescription/over-the counter
(OTC) sleep aids
- Pre-operative use of calcium channel blockers
- Insomnia
- Recent drug or alcohol abuse
- Psychiatric disorders other than anxiety, including depression
- Diabetes
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