Study of Cholesterol Levels and Types in African Americans With Type 2 Diabetes

Therapuetic Areas:Endocrinology
Age Range:18 - 79

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Preliminary Analysis of Lipoprotein Subclasses, Apoprotein Levels, and Genetic Architecture of African-American Males With Type 2 Diabetes. Lipids in African Americans With Type 2 Diabetes

Compared to other races, African-Americans with type 2 diabetes have different cholesterol
levels, specifically triglycerides and low density lipoprotein. Recent data has shown the
not only are cholesterol levels important in determining the risk for cardiovascular
disease, but the size of the cholesterol particles and surface proteins on the cholesterol
particles are also important. The objective of this study is to determine if
African-American males with diabetes have different particle size, surface proteins, and
cholesterol genetic links than African-American male without diabetes and Caucasian-American
males with and without diabetes.

African-American males with type 2 diabetes and not taking lipid-lowering medications are
the current target population. The results of their lab analysis will be compared to
results from a previous study conducted by Dr. Momary, a co-investigator,that included
African-American men without diabetes and Caucasian men with and without diabetes.

After obtaining an informed consent, a complete medical history will be obtained and
subjects will be examined, noninvasively, for physical signs of elevated cholesterol levels.
Afterwards, blood samples [one venous puncture, 6 tubes (21 mL total)] will be obtained.
Blood samples will be coded, sent to Berkeley Heart Lab and/or Clinical Laboratory Services,
and undergo genetic testing at Mercer University College of Pharmacy and Health Sciences.

Confidentiality of the subjects will be explained in the consenting process to the subjects.
All subject samples and information will be coded. Each subject will be given a subject
number upon consenting and this will be used throughout the study. All pertinent
information of the subjects will be listed under the designated number, but will not be
associated with that patient.

Inclusion Criteria:

- Male

- African American by self-report

- Subjects will be defined as having diabetes if they are diagnosed with diabetes per
the American Diabetes Association guidelines

- Subjects without diabetes or impaired glucose tolerance will have a fasting blood
glucose <100 mg/dL and/or an A1C<6.5%.

Exclusion Criteria:

- Females

- Self report of race or ethnicity other than African

- Currently taking any lipid-lowering medications
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Atlanta, GA
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Atlanta, Georgia 30303
Atlanta, GA
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