Mind-Body Medicine and Ulcerative Colitis
| Status: | Completed |
|---|---|
| Conditions: | Colitis, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 3/28/2019 |
| Start Date: | August 2011 |
| End Date: | July 2017 |
Stress has been linked to chronic health problems, particularly diseases involving
inflammation-mediated tissue injury and organ failure. Accordingly, it is not surprising that
mind/body interventions are advocated for treatment of chronic inflammatory diseases. One
such candidate disease is ulcerative colitis (UC) because: (1) UC is a life-long, relapsing,
disabling inflammatory disorder of the intestine that lacks a non-toxic, efficacious
treatment; (2) the therapeutic goal is to improve quality of life by ameliorating disabling
symptoms and preventing disease progression by preventing disease flare-up, (3) stress
triggers UC flare-up by modifying intestinal function and inflammatory processes,
highlighting the potential therapeutic benefit of reducing physiological stress responses.
The purpose of this study is to see if either of two 8-week mind/body medicine courses has an
effect in reducing stress and affecting the course and severity of UC. Both have been shown
to benefit other aspects of health and well-being.
inflammation-mediated tissue injury and organ failure. Accordingly, it is not surprising that
mind/body interventions are advocated for treatment of chronic inflammatory diseases. One
such candidate disease is ulcerative colitis (UC) because: (1) UC is a life-long, relapsing,
disabling inflammatory disorder of the intestine that lacks a non-toxic, efficacious
treatment; (2) the therapeutic goal is to improve quality of life by ameliorating disabling
symptoms and preventing disease progression by preventing disease flare-up, (3) stress
triggers UC flare-up by modifying intestinal function and inflammatory processes,
highlighting the potential therapeutic benefit of reducing physiological stress responses.
The purpose of this study is to see if either of two 8-week mind/body medicine courses has an
effect in reducing stress and affecting the course and severity of UC. Both have been shown
to benefit other aspects of health and well-being.
Inclusion Criteria:
- You have been diagnosed with moderately severe Ulcerative Colitis at the time of your
last flare up
- You experienced at least one flare-up within the last year
- Either no IBD medication or have been on a stable dose of oral 5-ASA products (i.e.
Mesalamine, Sulfasalazine, or Colazol) for at least 3 weeks, immunomodulators (Imuran,
6MP, Methotrexate)for at least 3 months and biologics (TNF antibody) for at least 6
months prior to enrollment
- If on maintenance 5-ASA products or immunomodulators and dose changes during the
study, participant agrees to remain on that dose for the study duration
- ACTIVE UC PATIENTS: If on Prednisone the dose must not be more than 20mg/day; you can
be weaned off Prednisone by 5mg/day weekly to 10mg/day weekly to 2.5mg/day weekly
Exclusion Criteria:
- Other forms of colitis, such as Clostridium Difficile Colitis or Indeterminate Colitis
- Current use of oral steroids within the last 30 days, topical agents (i.e. steroids or
5-ASA) within the last 14 days
- History of colon resection
- Antibiotic use within the last 14 days
- WOMEN: Cannot be pregnant
We found this trial at
1
site
1653 W. Congress Parkway
Chicago, Illinois 60612
Chicago, Illinois 60612
(312) 942-5000
Principal Investigator: Ali Keshavarzian, MD
Phone: 312-942-1181
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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