BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus

This research study hopes to identify new molecular markers in the tissue of Barrett's
esophagus that will help physicians better understand and manage this condition. Currently
there is very little understanding as to how Barrett's esophagus develops and why some people
with Barrett's esophagus go on to develop esophageal cancer. The purpose of this study is to
develop a better understanding of how these processes occur. The investigators also hope to
use the information from this study to identify new molecular markers that the investigators
can use to better determine who will or will not go on to develop esophageal cancer. Patients
who have been diagnosed in the past with Barrett's esophagus will be asked to participate.
Patients without Barrett's esophagus will be asked to take part so that the investigators can
compare tissue from patients without the conditions to those with the conditions.

Inclusion Criteria:

For BE patients:

- History of histologically confirmed BE, defined as endoscopically-suspected BE with
intestinal metaplasia with globlet cells on esophageal biopsies,

- BE length C1M1 or C0M2

- Age 18 years

Exclusion Criteria:

- History of gastric or esophageal surgery

- Inability to give informed consent

- Erosive esophagitis seen on upper endoscopy

- History of prior endoscopic therapy for BE 5 (for controls) History of intestinal
metaplasia on previous esophageal, GE junction or cardia biopsies.