A Study to Establish the Efficacy of QBX258 in Patients With Moderate to Severe Asthma

Inclusion Criteria:

- Patients with atopic asthma >1 year duration diagnosed according to the GINA
guidelines.

- Subjects must weigh at least 50 kg to participate in the study, and must have a body
mass index (BMI) within the range of 18 - 39 kg/m2.

- Asthma which is not adequately controlled on current treatment, as demonstrated by an
Asthma Control Questionnaire (ACQ) score of > 1.5.

- FEV1 40 to 90% of predicted.

Exclusion Criteria:

- Diagnosed with COPD as defined by the GOLD guidelines

- Subjects who have had a respiratory tract infection within 4 weeks prior to
screening.

- Women of child-bearing potential must use highly effective methods of contraception
during dosing and for at least 18 weeks after last study drug administration