The Young Women's Breast Cancer Study



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 40
Updated:2/22/2019
Start Date:November 2006
End Date:January 2026

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Helping Ourselves, Helping Others: The Young Women's Breast Cancer Study

The investigators are conducting a longitudinal cohort study of young women with breast
cancer. The investigators identify women age 40 and younger with newly-diagnosed breast
cancer from academic and community healthcare institutions. After women consent to the study,
they fill-out surveys and give blood samples, and the investigators collect tissue from their
breast cancer tumor after it is removed. Women are surveyed every 6 months for the first 3
years after diagnosis, then yearly thereafter for an additional 7 years (for a total
follow-up of at least 10 years following diagnosis). The study investigates short and
long-term disease and treatment issues, tumor biology and the relationship to patient
outcomes, and psychosocial concerns at baseline and in follow-up among a cohort of young
women who are newly-diagnosed with breast cancer.

This is a longitudinal cohort study of young women with breast cancer. Over a 6-year period,
the investigators aim to identify over 1,600 women age 40 and younger with newly diagnosed
breast cancer from academic and community health care institutions. It is anticipated that
1,300 of these women will agree to participate in an observational study. Patient surveys,
medical record review, and blood and tissue collection will be utilized. Women will be
surveyed every 6 months for the first 3 years after diagnosis, then yearly thereafter for an
additional 7 years (for a total follow-up of 10 year following diagnosis). The study will
investigate short and long-term disease and treatment issues, and psychosocial concerns at
baseline and in follow-up among a cohort of young women (age 40 or younger) newly diagnosed
with breast cancer. The investigators aim to characterize the population of young women at
diagnosis and in follow-up regarding disease and psychosocial outcomes (e.g., presentation
and disease characteristics, treatment patterns and quality of care, short and long-term side
effects, and psychosocial concerns including fertility, sexual functioning, and menopausal
issues). The investigators will also collect tumor and blood specimens to characterize the
tumors, and bank for future studies including molecular evaluations of disease
characteristics, genetic variability and hormonal levels in blood. Ultimately, the
investigators aim to develop predictors of outcome, and identify areas that may be amenable
to intervention.

Inclusion Criteria:

- Female

- Diagnosis of breast cancer

- Age 40 or younger at diagnosis

- Informed consent obtained from patient

- Ability to understand written and spoken English to the extent necessary to complete
the questionnaires

Exclusion Criteria:

- Inability to understand written and spoken English to the extent necessary to complete
the questionnaires

- Absence of informed consent
We found this trial at
13
sites
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Lidia Schapira, MD
Phone: 617-726-1923
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Steven Come, MD
Phone: 617-632-7886
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Aurora, Colorado 80045
Principal Investigator: Virginia Borges, MD
Phone: 720-848-8031
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Ann H Partridge, MD, MPH
Phone: 617-632-4983
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Danvers, Massachusetts 01923
Principal Investigator: Therese Mulvey, MD
Phone: 978-882-6044
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Hyannis, Massachusetts 02601
Principal Investigator: Frank G Basile, MD
Phone: 508-862-5799
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Londonderry, New Hampshire
Principal Investigator: Jeanna Walsh, MD
Phone: 603-552-9190
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295 Varnum Ave
Lowell, Massachusetts 01854
(978) 937-6000
Principal Investigator: Blair Ardman, MD
Phone: 978-788-7227
Lowell General Hospital Welcome to Lowell General Hospital! Our goal is to provide you with...
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Milford, Massachusetts 01757
Principal Investigator: Natalie Sinclair, MD
Phone: 508-488-3718
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2014 Washington St
Newton, Massachusetts 02462
(617) 243-6000
Principal Investigator: Caroline Block, MD
Phone: 617-243-6392
Newton-Wellesley Hospital A comprehensive medical center located right in Newton on Washington Street, Newton-Wellesley Hospital...
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Rochester, Minnesota 55905
Principal Investigator: Kathryn Ruddy, MD, MPH
Phone: 507-266-3867
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South Weymouth, Massachusetts 02190
Principal Investigator: Katherina Zabicki Calvillo, MD, FACS
Phone: 781-624-4788
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Toronto, Ontario
Principal Investigator: Ellen Warner, MD
Phone: 416-480-4065
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