ARTDeCo Study: A Study of RO4995819 in Patients With Major Depressive Disorder And Inadequate Response to Ongoing Antidepressant Treatment



Status:Completed
Conditions:Depression, Major Depression Disorder (MDD)
Therapuetic Areas:Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - 65
Updated:8/3/2016
Start Date:December 2011
End Date:June 2014

Use our guide to learn which trials are right for you!

A Multi Center, Randomized, Double-blind, Placebo Controlled, Parallel-group Study to Investigate the Efficacy and Safety of RO4995819 Versus Placebo, as Adjunctive Therapy in Patients With Major Depressive Disorder Having Inadequate Response to Ongoing Antidepressant Treatment (ARTDeCo)

This multi-center, randomized, double-blind, placebo-controlled, parallel-group study will
investigate the efficacy and safety of RO4995819 as adjunctive therapy in patients with
major depressive disorder having inadequate response to ongoing antidepressant treatment.
Patients will be randomized to receive once daily doses of 5 mg, 15 or 30 mg of RO4995819 or
matching placebo. The anticipated time on study treatment is 6 weeks.


Inclusion Criteria:

- Adult patients, 18-65 years of age

- Major depression disorder without psychotic features

- Inadequate response to current, ongoing antidepressant treatment as defined by
protocol

- Having at least one but no more than 2 antidepressant treatment trial failures

- Body mass index (BMI) 18.0-35.0 kg/m2 inclusive

Exclusion Criteria:

- Patient currently receives treatment with a combination of 3 or more antidepressants

- Significant ongoing use of high doses of barbiturates, benzodiazepines or other
anxiolytic drugs

- Patient previously received RO4995819

- Patient participated in an investigational drug or device trial within 6 months of
screening

- History of non-response to, or current use of non-pharmacological treatment including
Electroconvulsive Therapy (ECT), Vagus Nerve Stimulation (VNS), or Repetitive
Transcranial Magnetic Stimulation (RTMS)

- Past or present psychotic symptoms
We found this trial at
44
sites
?
mi
from
Oakland, CA
Click here to add this to my saved trials
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
?
mi
from
Arlington, TX
Click here to add this to my saved trials
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
?
mi
from
Beachwood, OH
Click here to add this to my saved trials
?
mi
from
Boston, MA
Click here to add this to my saved trials
?
mi
from
Canton, OH
Click here to add this to my saved trials
?
mi
from
Chicago, IL
Click here to add this to my saved trials
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
?
mi
from
Columbia, SC
Click here to add this to my saved trials
?
mi
from
Coral Springs, FL
Click here to add this to my saved trials
?
mi
from
Denver, CO
Click here to add this to my saved trials
?
mi
from
Durham, NC
Click here to add this to my saved trials
?
mi
from
Flowood, MS
Click here to add this to my saved trials
?
mi
from
Gainsville, FL
Click here to add this to my saved trials
?
mi
from
Houston, TX
Click here to add this to my saved trials
?
mi
from
Innsbruck,
Click here to add this to my saved trials
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
?
mi
from
Jenkintown, PA
Click here to add this to my saved trials
?
mi
from
Lauderhill, FL
Click here to add this to my saved trials
?
mi
from
Media, PA
Click here to add this to my saved trials
?
mi
from
New York, NY
Click here to add this to my saved trials
?
mi
from
New York, NY
Click here to add this to my saved trials
?
mi
from
New York, NY
Click here to add this to my saved trials
?
mi
from
North Miami, FL
Click here to add this to my saved trials
?
mi
from
O'Fallon, MO
Click here to add this to my saved trials
?
mi
from
Ocala, FL
Click here to add this to my saved trials
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
?
mi
from
Prairie Village, KS
Click here to add this to my saved trials
?
mi
from
Redlands, CA
Click here to add this to my saved trials
?
mi
from
Richmond, VA
Click here to add this to my saved trials
?
mi
from
Roanoke, VA
Click here to add this to my saved trials
?
mi
from
Rochester, NY
Click here to add this to my saved trials
?
mi
from
Roswell, GA
Click here to add this to my saved trials
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
?
mi
from
San Diego, CA
Click here to add this to my saved trials
?
mi
from
Smyrna, GA
Click here to add this to my saved trials
?
mi
from
Stanford, CA
Click here to add this to my saved trials
?
mi
from
Torrance, CA
Click here to add this to my saved trials
?
mi
from
Victorville, CA
Click here to add this to my saved trials
?
mi
from
Watertown, MA
Click here to add this to my saved trials
?
mi
from
Wichita, KS
Click here to add this to my saved trials