Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging

Status:	Completed
Conditions:	High Blood Pressure (Hypertension)
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	18 - 99
Updated:	4/21/2016
Start Date:	August 2011
End Date:	June 2014

Cardiac magnetic resonance imaging has emerged as a potential valuable test for the early
detection of Pulmonary Arterial Hypertension. A number of reports have provided some
preliminary evidence that Pulmonary Artery (PA) stiffness may be accurately detected by
imaging of the pulmonary artery in order to measure PA stiffness. In addition, cardiac MRI
could play provide early and effective treatment for Pulmonary Arterial Hypertension (PAH).

Inclusion Criteria:

Consecutive patients aged ≥ 18 years with PAH as dictated by a comprehensive examination
and echocardiography will be included for enrollment.

Exclusion Criteria:

- Age < 18 years

- Pregnancy

- Mechanical ventilation

- Acute or chronic renal failure (creatinine clearance < 30 ml/min or requiring renal
replacement therapy)

- Inability to perform MRI (i.e. claustrophobia, severe obesity (> 150 kg), device
incompatible with MRI)

- Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e. atrial
fibrillation with highly variable cycle lengths)

- Prior heart or lung transplantation

- Left ventricular systolic (ejection fraction < 50%) or diastolic failure (based on
Framingham criteria for heart failure with preserved ejection fraction)

- Significant left-sided valvular disease (≥ moderate aortic stenosis, mitral stenosis,
aortic regurgitation, mitral regurgitation) or prior valve surgery

We found this trial at

sites

Mayo Clinic

4201 Belfort Road
Jacksonville, Florida 32216

(408) 293-2336