COroNary CT Angiography Evaluation For Clinical Outcomes: An InteRnational Multicenter Registry (CONFIRM)



Status:Enrolling by invitation
Conditions:Peripheral Vascular Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:1/6/2019
Start Date:June 2003
End Date:January 2026

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COronary CT Angiography Evaluation For Clinical Outcomes: An International Multicenter Registry

The CONFIRM study was developed to examine the prognostic value of cardiac computed
tomographic angiography (CCTA) findings for prediction of future adverse cardiac events
related to coronary artery disease (CAD) in a large, international patient population. The
purpose of this multicenter registry is to correlate coronary and non-coronary cardiac
findings by CCTA with demographic and clinical data for refinement of risk stratification of
individuals with suspected or known CAD.

Coronary computed tomographic angiography (CCTA) of 64-detector rows or greater represents a
novel noninvasive anatomic method for evaluation of patients with suspected coronary artery
disease (CAD). Early studies suggest a potential for prognostic risk assessment by CCTA
findings but were limited by small patient cohorts or single centers. The CONFIRM Registry is
a large, prospective, multinational dynamic observational study of patients undergoing CCTA.
The primary aim of CONFIRM is to determine the prognostic value of CCTA findings for the
prediction of future adverse CAD events.

The CONFIRM registry currently represents 27,125 consecutive patients at 12 cluster sites in
6 countries in North America, Europe, and Asia. CONFIRM sites were chosen on the basis of
adequate CCTA volume, site CCTA proficiency, and local demographic characteristics and
medical facilities to ensure a broad-based sample of patients. Patients comprising the
present CONFIRM cohort include those with suspected but without known CAD, with known CAD, or
asymptomatic persons undergoing CAD evaluation. A data dictionary comprising a wide array of
demographic, clinical, and CCTA findings was developed by the CONFIRM investigators and is
uniformly used for all patients. Patients are followed up after CCTA performance to identify
adverse CAD events, including death, myocardial infarction, unstable angina, target vessel
revascularization, and CAD-related hospitalization.

All consecutive patients at cluster sites meeting all inclusion criteria undergoing CCTA of
64-detector rows or greater will be included within the CONFIRM registry.

Inclusion Criteria:

1. Age > 18 years

2. Evaluation by CCTA with 64-detector rows or greater for CAD evaluation as part of
standard of care

3. Interpretable CCTA

4. Prospective data collection for CAD risk factors.

Exclusion Criteria:

No explicit patient exclusion criteria are defined.
We found this trial at
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New York, New York 10065
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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8900 North Kendall Drive
Miami, Florida 33176
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Albany, New York 12208
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2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
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Hendersonville, Tennessee
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Innsbruck,
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Los Angeles, California 90502
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Royal Oak, Michigan 48073
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6900 Georgia Ave NW
Washington, District of Columbia 20307
(202) 782-6849
Walter Reed Army Medical Center The Walter Reed National Military Medical Center is one of...
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