Open Label Study of Long Term Evaluation Against LDL-C Trial



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 75
Updated:11/4/2018
Start Date:October 7, 2011
End Date:June 20, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Multicenter, Controlled, Open-label Extension (OLE) Study to Assess the Long-term Safety and Efficacy of AMG 145 (Evolocumab)

The primary clinical hypothesis is that long-term exposure of evolocumab (AMG 145) will be
safe and well tolerated in subjects with hypercholesterolemia.


Inclusion Criteria:

- Complete a qualifying evolocumab (AMG 145) parent study protocol

Exclusion Criteria:

- Experienced a treatment-related serious adverse event that led to IP discontinuation
in the parent study

- Have an unstable medical condition, in the judgment of the investigator

- Known sensitivity to any of the products to be administered during dosing

- Currently enrolled in another investigational device or drug study (excluding
evolocumab (AMG 145) parent study), or less than 30 days since ending another
investigational device or drug study(s),or receiving other investigational agent(s)
We found this trial at
70
sites
Clinical Trial Facility in Chevy Chase Maryland
Chevy Chase, Maryland 20815
2278
mi
from 91732
Chevy Chase, MD
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Clinical Trial Facility in Akron Ohio
Akron, Ohio
2040
mi
from 91732
Akron, OH
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Clinical Trial Facility in Anaheim California
Anaheim, California 92801
16
mi
from 91732
Anaheim, CA
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Clinical Trial Facility in Arlington Texas
Arlington, Texas 76017
1204
mi
from 91732
Arlington, TX
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Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
1919
mi
from 91732
Atlanta, GA
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Clinical Trial Facility in Auburn Maine
Auburn, Maine 04210
2615
mi
from 91732
Auburn, ME
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Clinical Trial Facility in Bethesda Maryland
Bethesda, Maryland
2277
mi
from 91732
Bethesda, MD
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
1784
mi
from 91732
Birmingham, AL
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Clinical Trial Facility in Bristol Tennessee
Bristol, Tennessee 37620
2016
mi
from 91732
Bristol, TN
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Clinical Trial Facility in Brockton Massachusetts
Brockton, Massachusetts 02301
2581
mi
from 91732
Brockton, MA
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Clinical Trial Facility in Brooklyn Center Minnesota
Brooklyn Center, Minnesota 55430
1510
mi
from 91732
Brooklyn Center, MN
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Clinical Trial Facility in Cadiz Ohio
Cadiz, Ohio 43907
2066
mi
from 91732
Cadiz, OH
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Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
2281
mi
from 91732
Camp Hill, PA
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Clinical Trial Facility in Camperdown New South Wales
Camperdown, New South Wales 2050
7516
mi
from 91732
Camperdown,
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Clinical Trial Facility in Carmichael California
Carmichael, California 95608
364
mi
from 91732
Carmichael, CA
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Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
1729
mi
from 91732
Chicago, IL
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
1880
mi
from 91732
Cincinnati, OH
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Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
2032
mi
from 91732
Cleveland, OH
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Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
804
mi
from 91732
Colorado Springs, CO
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Clinical Trial Facility in Cortlandt Manor New York
Cortlandt Manor, New York 10567
2436
mi
from 91732
Cortlandt Manor, NY
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Clinical Trial Facility in Dayton Ohio
Dayton, Ohio 45409
1897
mi
from 91732
Dayton, OH
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Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
2187
mi
from 91732
Daytona Beach, FL
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Clinical Trial Facility in DeLand Florida
DeLand, Florida 32720
?
mi
from 91732
DeLand, FL
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Clinical Trial Facility in Duncansville Pennsylvania
Duncansville, Pennsylvania 16635
2200
mi
from 91732
Duncansville, PA
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Clinical Trial Facility in Endwell New York
Endwell, New York
2324
mi
from 91732
Endwell, NY
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Clinical Trial Facility in Fargo North Dakota
Fargo, North Dakota 58122
1400
mi
from 91732
Fargo, ND
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Clinical Trial Facility in Great Falls Montana
Great Falls, Montana 59405
991
mi
from 91732
Great Falls, MT
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Clinical Trial Facility in Green Cove Springs Florida
Green Cove Springs, Florida
2135
mi
from 91732
Green Cove Springs, FL
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Clinical Trial Facility in Henderson Nevada
Henderson, Nevada
218
mi
from 91732
Henderson, NV
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Clinical Trial Facility in Houston Texas
Houston, Texas
1357
mi
from 91732
Houston, TX
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Clinical Trial Facility in Indianapolis Indiana
Indianapolis, Indiana 46202
1793
mi
from 91732
Indianapolis, IN
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Clinical Trial Facility in Inglewood California
Inglewood, California 90301
21
mi
from 91732
Inglewood, CA
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Clinical Trial Facility in Iowa City Iowa
Iowa City, Iowa 52242
1528
mi
from 91732
Iowa City, IA
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Clinical Trial Facility in Jacksonville Florida
Jacksonville, Florida 32209
2127
mi
from 91732
Jacksonville, FL
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Clinical Trial Facility in Las Vegas Nevada
Las Vegas, Nevada 89135
208
mi
from 91732
Las Vegas, NV
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Clinical Trial Facility in Little Rock Arkansas
Little Rock, Arkansas
1463
mi
from 91732
Little Rock, AR
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Clinical Trial Facility in Littleton Colorado
Littleton, Colorado 80120
813
mi
from 91732
Littleton, CO
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Clinical Trial Facility in Louisville Kentucky
Louisville, Kentucky 40202
1813
mi
from 91732
Louisville, KY
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Clinical Trial Facility in Malvern Arkansas
Malvern, Arkansas 72104
1436
mi
from 91732
Malvern, AR
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Clinical Trial Facility in Marquette Michigan
Marquette, Michigan
1812
mi
from 91732
Marquette, MI
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Clinical Trial Facility in Melbourne Florida
Melbourne, Florida
2239
mi
from 91732
Melbourne, FL
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Clinical Trial Facility in Miami Florida
Miami, Florida 33136
2321
mi
from 91732
Miami, FL
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Clinical Trial Facility in Mission Viejo California
Mission Viejo, California 92691
37
mi
from 91732
Mission Viejo, CA
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Clinical Trial Facility in Mount Pleasant South Carolina
Mount Pleasant, South Carolina 29464
2187
mi
from 91732
Mount Pleasant, SC
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Clinical Trial Facility in Munster Indiana
Munster, Indiana 46321
1733
mi
from 91732
Munster, IN
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Clinical Trial Facility in New York New York
New York, New York 10032
2435
mi
from 91732
New York, NY
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Clinical Trial Facility in Newport Beach California
Newport Beach, California 92660
31
mi
from 91732
Newport Beach, CA
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Clinical Trial Facility in Norfolk Virginia
Norfolk, Virginia 23507
2336
mi
from 91732
Norfolk, VA
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Clinical Trial Facility in Norman Oklahoma
Norman, Oklahoma 73069
1169
mi
from 91732
Norman, OK
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Clinical Trial Facility in Oklahoma City Oklahoma
Oklahoma City, Oklahoma
1164
mi
from 91732
Oklahoma City, OK
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Clinical Trial Facility in Pittsburgh Pennsylvania
Pittsburgh, Pennsylvania
2119
mi
from 91732
Pittsburgh, PA
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Clinical Trial Facility in Ponte Vedra Florida
Ponte Vedra, Florida 32081
2150
mi
from 91732
Ponte Vedra, FL
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Clinical Trial Facility in Port Charlotte Florida
Port Charlotte, Florida 33952
2180
mi
from 91732
Port Charlotte, FL
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Clinical Trial Facility in Portland Maine
Portland, Maine 04102
2614
mi
from 91732
Portland, ME
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Clinical Trial Facility in Raleigh North Carolina
Raleigh, North Carolina 27607
2214
mi
from 91732
Raleigh, NC
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Clinical Trial Facility in Rapid City South Dakota
Rapid City, South Dakota 57701
1049
mi
from 91732
Rapid City, SD
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Clinical Trial Facility in Renton Washington
Renton, Washington 98057
943
mi
from 91732
Renton, WA
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Clinical Trial Facility in Richmond Virginia
Richmond, Virginia 23227
2267
mi
from 91732
Richmond, VA
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Clinical Trial Facility in San Antonio Texas
San Antonio, Texas 78224
1188
mi
from 91732
San Antonio, TX
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Clinical Trial Facility in Sanford Florida
Sanford, Florida 32771
2184
mi
from 91732
Sanford, FL
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Clinical Trial Facility in Savannah Georgia
Savannah, Georgia 31406
2131
mi
from 91732
Savannah, GA
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Clinical Trial Facility in Seattle Washington
Seattle, Washington 98105
964
mi
from 91732
Seattle, WA
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Clinical Trial Facility in Tacoma Washington
Tacoma, Washington
939
mi
from 91732
Tacoma, WA
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Clinical Trial Facility in Thousand Oaks California
Thousand Oaks, California 91360
50
mi
from 91732
Thousand Oaks, CA
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Clinical Trial Facility in Tucson Arizona
Tucson, Arizona 85724
427
mi
from 91732
Tucson, AZ
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Clinical Trial Facility in Tupelo Mississippi
Tupelo, Mississippi 38801
1666
mi
from 91732
Tupelo, MS
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Clinical Trial Facility in Tustin California
Tustin, California 92780
25
mi
from 91732
Tustin, CA
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Clinical Trial Facility in Williamsville New York
Williamsville, New York 14221
2188
mi
from 91732
Williamsville, NY
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Clinical Trial Facility in Winston-Salem North Carolina
Winston-Salem, North Carolina
2126
mi
from 91732
Winston-Salem, NC
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Clinical Trial Facility in York Pennsylvania
York, Pennsylvania 17405
2299
mi
from 91732
York, PA
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