Pilot Study of Varenicline to Treat Opioid Dependence
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain, Chronic Pain, Psychiatric, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Musculoskeletal, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | June 2011 |
| End Date: | June 2013 |
| Contact: | William M. Hooten, MD |
| Email: | hooten.william@mayo.edu |
| Phone: | 507-255-7547 |
The Role of Varenicline in Treating Opioid Dependence: A Pilot Study
The objective of this proposal is to explore the potential of varenicline as a
pharmacotherapeutic agent for opioid dependence and addiction.
Inclusion criteria
- Age>=21 years
- Use of opioids at admission to PRC, with daily morphine equivalent dose>=60mg
- Be able and willing to participate fully in all aspects of the study including one
month follow-up after completion of PRC
- Ability to provide informed consent
Exclusion criteria
- Currently using varenicline or other pharmacotherapy for nicotine dependence
- Currently pregnant, lactating, or likely to become pregnant during the trial and not
willing to use an acceptable form of contraception;
- History of a major cardiovascular event in the past 6 months including unstable
angina, acute myocardial infarction, stroke, or coronary angioplasty;
- Known varenicline allergy
- Use of any medication (e.g., methadone, Suboxone) as maintenance therapy for opiate
addiction
- Identification of illicit drugs (e.g., marijuana, cocaine) on the baseline urine
toxicology screen
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