Effect of Vitamin D Supplementation on In-vitro Fertilization (IVF) Outcomes



Status:Recruiting
Conditions:Other Indications, Women's Studies, Gastrointestinal, Infertility
Therapuetic Areas:Gastroenterology, Other, Reproductive
Healthy:No
Age Range:18 - 38
Updated:3/1/2014
Start Date:August 2011
Contact:Lia Bernardi, MD
Email:lia.a.bernardi@gmail.com

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Randomized Controlled Trial: The Effects of Vitamin D Supplementation on In-vitro Fertilization Outcomes

Historically, vitamin D has been considered to play a role solely in bone and calcium
metabolism. Numerous studies have suggested a link between vitamin D deficiency and adverse
health outcomes such as malignancy, cardiovascular disease, immune functioning, and glucose
metabolism. In the obstetrics literature, vitamin D deficiency has been linked to
preeclampsia, gestational diabetes, and increased rate of cesarean section rate. Recent
data from retrospective chart reviews have demonstrated a possible role of vitamin D in
implantation and clinical pregnancy rates in patients undergoing in-vitro fertilization.
Patients found to be deficient in vitamin D were found to have significantly lower clinical
pregnancy rates when compared to patients who were replete in vitamin D levels. Currently,
there are no prospective clinical trials investigating the effects of vitamin D
supplementation on IVF outcomes such as clinical pregnancy rate and implantation rates. The
investigators hypothesize that the vitamin D supplementation in patients found to be either
deficient or insufficient in vitamin D will lead to improved pregnancy rates in infertility
patients undergoing in-vitro fertilization.

The trial will not pay for or subsidize for IVF treatment. Participants will receive blood
Vitamin D screening test and any necessary supplements free of charge.

Inclusion Criteria:

- Infertile women aged ≤ 38 years undergoing fresh invitro fertilization cycles

Exclusion Criteria:

- Infertile women aged > 38 undergoing fresh invitro fertilization cycles

- Patients undergoing frozen embryo transfers

- Patients undergoing donor-egg cycles

- Patients who have a contraindication to receiving Vitamin D (e.g. patients with
history of primary hyperparathyroidism, sarcoidosis, tuberculosis, kidney disease, or
lymphoma)
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