A Study to Evaluate the Impact of MABT5102A on Brain Amyloid Load and Related Biomarkers in Patients With Mild to Moderate Alzheimer's Disease



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:50 - 80
Updated:8/3/2016
Start Date:August 2011
End Date:April 2014

Use our guide to learn which trials are right for you!

A Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter, Phase II Study to Evaluate the Impact of MABT5102A on Brain Amyloid Load and Related Biomarkers in Patients With Mild to Moderate Alzheimer's Disease

This is a Phase II, randomized, double-blind, parallel-group, placebo-controlled study to
evaluate the effects of MABT5102A on brain amyloid burden (as assessed by amyloid PET
imaging) and other biomarkers in patients with mild to moderate Alzheimer's disease.


Inclusion Criteria:

- Diagnosis of probable AD according to the NINCDS-ADRDA criteria

- MMSE score of 18-26 points at screening

- GDS-15 score of < 6

- Completion of 6 years of education (or good work history consistent with exclusion of
mental retardation or other pervasive developmental disorders)

- For patients currently receiving treatment with approved AD treatments (AChE
inhibitors or memantine): Treatment initiated and continued for at least the last 3
months prior to randomization, at a stable dose for at least the last 2 months prior
to randomization

Exclusion Criteria:

- Severe or unstable medical condition that, in the opinion of the investigator or
Sponsor, would interfere with the patient's ability to complete the study assessments
or would require the equivalent of institutional or hospital care

- History or presence of clinically evident vascular disease potentially affecting the
brain (e.g., stroke, clinically significant carotid or vertebral stenosis or plaque,
aortic aneurysm, intracranial aneurysm, cerebral hemorrhage, arteriovenous
malformation)

- History of severe, clinically significant (persistent neurologic deficit or
structural brain damage) central nervous system trauma (e.g., cerebral contusion)

- Hospitalization within 4 weeks prior to screening

- Previous treatment with MABT5102A or any other therapeutic that targets Abeta

- Treatment with any biologic therapy within 5 half-lives or 3 months prior to
screening, whichever is longer, with the exception of routinely recommended
vaccinations, which are allowed
We found this trial at
23
sites
2377
mi
from 91732
Jenkintown, PA
Click here to add this to my saved trials
1924
mi
from 91732
Decatur, GA
Click here to add this to my saved trials
East Providence, Rhode Island 02915
2564
mi
from 91732
East Providence, RI
Click here to add this to my saved trials
2431
mi
from 91732
Eatontown, NJ
Click here to add this to my saved trials
Elk Grove Village, Illinois 60007
1711
mi
from 91732
Elk Grove Village, IL
Click here to add this to my saved trials
2204
mi
from 91732
Fort Myers, FL
Click here to add this to my saved trials
207
mi
from 91732
Fresno, CA
Click here to add this to my saved trials
2202
mi
from 91732
Ft Myers, FL
Click here to add this to my saved trials
Hallandale Beach, Florida 33009
2318
mi
from 91732
Hallandale Beach, FL
Click here to add this to my saved trials
1676
mi
from 91732
Hattiesburg, MS
Click here to add this to my saved trials
208
mi
from 91732
Las Vegas, NV
Click here to add this to my saved trials
13
mi
from 91732
Los Angeles, CA
Click here to add this to my saved trials
2448
mi
from 91732
Manhasset, NY
Click here to add this to my saved trials
5787
mi
from 91732
Nancy,
Click here to add this to my saved trials
2182
mi
from 91732
Orlando, FL
Click here to add this to my saved trials
67
mi
from 91732
Oxnard, CA
Click here to add this to my saved trials
329
mi
from 91732
Palo Alto, CA
Click here to add this to my saved trials
343
mi
from 91732
Phoenix, AZ
Click here to add this to my saved trials
2562
mi
from 91732
Providence, RI
Click here to add this to my saved trials
397
mi
from 91732
Santa Rosa, CA
Click here to add this to my saved trials
330
mi
from 91732
Sun City, AZ
Click here to add this to my saved trials
1938
mi
from 91732
Toledo, OH
Click here to add this to my saved trials
427
mi
from 91732
Tucson, AZ
Click here to add this to my saved trials