Dasatinib Added to Gemcitabine for Subjects With Locally-advanced Pancreatic Cancer



Status:Completed
Conditions:Cancer, Cancer, Pancreatic Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:June 2011
End Date:March 2015

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Placebo-controlled Double-blind Trial of Dasatinib Added to Gemcitabine for Subjects With Locally-advanced Pancreatic Cancer

The purpose of this study is to determine whether patients with locally advanced pancreatic
cancer who receive dasatinib added to standard of care (gemcitabine) live longer, compared
to patients who receive standard of care (gemcitabine) plus placebo; i.e. gemcitabine alone.


Inclusion Criteria:

- Histologic or cytologic documentation of unresectable adenocarcinoma of the pancreas.

- Recovery from toxicity of previous procedures to establish the diagnosis. ECOG PS 0
or 1.

- Adequate organ function.

Exclusion Criteria:

- Evidence of metastatic disease.

- Previous radiotherapy or chemoradiotherapy.

- History of or current pleural effusion.

- History of significant cardiovascular disease.

- Clinically significant bleeding disorder or coagulopathy.

- Concomitant medication with strong CYP 3A4 inhibitor.
We found this trial at
12
sites
649
mi
from 91732
Albuquerque, NM
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825
mi
from 91732
Aurora, CO
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2361
mi
from 91732
Bethlehem, PA
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1784
mi
from 91732
Birmingham, AL
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216 Blacktown Road
Blacktown, New South Wales 2756
7524
mi
from 91732
Blacktown,
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2309
mi
from 91732
Boynton Beach, FL
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13
mi
from 91732
Los Angeles, CA
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1511
mi
from 91732
Minneapolis, MN
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21
mi
from 91732
Orange, CA
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355
mi
from 91732
San Francisco, CA
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2136
mi
from 91732
Tampa, FL
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1182
mi
from 91732
Wichita, KS
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