Comparative Study of EDP-420 Versus Another Antibiotic in the Treatment of Community Acquired Pneumonia

Inclusion Criteria:

- Recent respiratory illness with signs and symptoms and chest X-ray consistent with
the diagnosis of community-acquired pneumonia.

- Suitable candidate for oral antibiotic therapy and able to swallow large capsules
intact

- If female, must be non-lactating and at no risk for pregnancy

Exclusion Criteria:

- Other infections

- Other pulmonary diseases requirement multiple antibacterial medications or long
duration of therapy

- History of hypersensitivity, allergic or adverse reactions to macrolide, ketolide,
azalide or streptogramins

- Evidence of uncontrolled clinically significant disease, malignancy, or other
abnormality

- Requirement of parenteral antimicrobial therapy for treatment of pneumonia

- Currently receiving or likely to receive any known inhibitors or inducers of
cytochrome P450 mediated drug metabolism

- Immunocompromised subjects