Modulation of Cerebral Blood Flow Using Quercetin, a Nutritional Supplement
| Status: | Completed |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | June 2009 |
| End Date: | June 2012 |
| Contact: | Sarah LaRose, BA |
| Email: | sllarose@partners.org |
| Phone: | 617-525-6849 |
Hypoxia-inducible Transcription Factor 1 (HIF-1) in Vascular Aging
The purpose of this study is to find out if quercetin can increase blood levels of
hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a
corresponding increase in blood flow to the brain.
Inclusion Criteria:
- healthy volunteers between the ages of 18-75 years old
Exclusion Criteria:
- subjects taking vasoactive medications
- hypertension or vascular disease
- asthma
- smokers
- pregnant women
- cancer
- diabetes mellitus
- history of seizures
- history of stroke or head trauma
- subjects taking digoxin, cyclosporine,felodipine, estradiol, or quinolone antibiotics
- poor transcranial Doppler insonation windows
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