Drug Interaction Study Between Antimalarial and Anti-HIV Medications

The purpose of this study is to find out whether taking certain anti-HIV medicines with
certain antimalarial medicines affects the amount of the medicines in the blood.

The study medicines that will be used are artemether/lumefantrine (antimalarial medication)
and lopinavir/ritonavir or efavirenz (anti-HIV medications). Artemether/lumefantrine is not
approved by the United States Food and Drug Administration (FDA) but is recommended as
standard of care medical treatment for malaria in Africa and Asia. Lopinavir/ritonavir and
efavirenz are approved by the FDA. Artemether/lumefantrine and lopinavir/ritonavir or
efavirenz may need to be used together to treat children in Africa and Asia. We seek to
learn about whether or not the use of these medicines together results in a change in blood
levels of any of these medicines. The information obtained from this study will help doctors
to provide a better treatment to children and adults with malaria and HIV.