ARCHER 1009 : A Study Of Dacomitinib (PF-00299804) Vs. Erlotinib In The Treatment Of Advanced Non-Small Cell Lung Cancer



Status:Completed
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:June 2011
End Date:September 2015

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Archer 1009: A Randomized, Double Blind Phase 3 Efficacy And Safety Study Of PF-00299804 (Dacomitinib) Versus Erlotinib For The Treatment Of Advanced Non-Small Cell Lung Cancer Following Progression After, Or Intolerance To, At Least One Prior Chemotherapy

This is a multinational, multicenter, randomized,double-blinded, Phase 3 study comparing the
efficacy and safety of treatment with PF-00299804 to treatment with erlotinib in patients
with advanced non-small cell lung cancer, previously treated with at least one prior
regimen. Analyses of primary objective (Progression Free Survival) will be done in two
co-primary populations as defined in the protocol.


Inclusion Criteria:

- Evidence of pathologically confirmed, advanced NSCLC (with known histology).

- Prior treatment with at least one and no more than two systemic therapy regimens (at
least one must be standard chemotherapy for advanced NSCLC).

- Adequate tissue sample must be submitted prior to randomization for tumor biomarker
analyses.

- Adequate renal, hematologic, liver function.

- ECOG PS of 0-2.

- Radiologically measurable disease.

Exclusion Criteria:

- Small cell histology.

- Symptomatic brain mets or known leptomeningeal mets.

- Prior therapy with agent known or proposed to be active by action on EGFR tyrosine
kinase or other HER family proteins.

- Uncontrolled medical disorders.
We found this trial at
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Rogers, Arkansas 72758
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
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220 S Palisade Dr # 204
Santa Maria, California 93454
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825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Alhambra, California 91801
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Arlington Heights, Illinois 60005
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Atlanta, Georgia 30322
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1365 Clifton Rd NE
Atlanta, Georgia 30322
(404) 778-1900
Winship Cancer Institute at Emory University Winship Cancer Institute of Emory University is Georgia
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550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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1364 Clifton Rd NE
Atlanta, Georgia 30322
(404) 712-2000
Emory University Hospital As the largest health care system in Georgia and the only health...
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Austell, GA
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Carrollton, Georgia 30117
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Cartersville, Georgia 30121
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1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
John B. Amos Cancer Center The John B. Amos Cancer Center located in Columbus, Georgia,...
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Corvallis, Oregon 97330
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Creve Couer, Missouri 63141
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Decatur, Georgia 30033
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Denville, New Jersey 07834
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Detroit, Michigan 48201
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Douglasville, Georgia 30134
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Duarte, California 91010
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Evansville, Indiana 47713
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Farmington Hills, Michigan 48334
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Fayetteville, Arkansas 72703
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Florence, Alabama 35630
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Fullerton, California 92835
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Gainesville, Georgia 30501
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Gainesville, Georgia 30501
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743 Spring St NE
Gainesville, Georgia 30501
770-219-9000
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1 Ingalls Dr
Harvey, Illinois 60426
(708) 333-2300
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Harvey, Illinois 60426
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Hazard, Kentucky 41701
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Hickory, North Carolina 28602
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Kennewick, Washington 99336
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Lawrenceville, Georgia 30046
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Lenoir, North Carolina 28645
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Lincoln City, Oregon 97367
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Los Angeles, California 90095
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Louisville, Kentucky 40202
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Louisville, Kentucky 40207
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500 S Preston St
Louisville, Kentucky
(502) 852-5555
University of Louisville The University of Louisville is a state supported research university located in...
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Marietta, Georgia 30060
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1660 Springhill Avenue
Mobile, Alabama 36604
(251) 665-8000
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Munster, Indiana 46321
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Muscle Shoals, Alabama 35661
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Niles, Illinois 60714
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Norwalk, Connecticut 06856
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Oklahoma City, Oklahoma 73112
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601 E Rollins St
Orlando, Florida 32803
(407) 303-5600
Florida Hospital Florida Hospital is one of the country
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Orlando, Florida 32804
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Redondo Beach, California 90277
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Richland, Washington 99352
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Saint Peters, Missouri 63376
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Santa Monica, California 90404
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1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
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Snellville, Georgia 30078
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South Pasadena, California 91030
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1 Barnes Jewish Hospital Plaza
St. Louis, Missouri 63110
(314) 747-3000
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3 Edmund D. Pellegrino Road
Stony Brook, New York 11794
(631) 638-1000
Stony Brook University Cancer Center Ask a cancer survivor. Having highly advanced care close to...
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Tinley Park, Illinois 60477
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Tyler, Texas 75702
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Valencia, California 91355
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Waco, Texas 76712
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