Physical Fitness, Cardiovascular and Brain Health

Cognition is the most important determinant of health status, quality of life and functional
ability in older age. Therefore, early interventions that preserve and enhance cognitive
function are crucial for ensuring successful aging. The most common treatable risk factor
for late-life cognitive impairment is midlife hypertension (HTN). One highly promising
intervention strategy is aerobic exercise as it has been associated cognitive benefits in
non-demented older adults. However, it is still unclear whether this benefit is due simply
to prevention of other risk factors (e.g., reductions in blood pressure) or if exercise can
reverse the negative effects of HTN on the brain. The goals of the current study are to
employ sensitive measures of neuroimaging and cognition in order to 1).Compare cerebral
health in endurance trained versus sedentary middle aged adults with normal or borderline to
stage 1 hypertension, 2). measure the effects of exercise training in previously sedentary
middle aged adults adults with normal or borderline to stage 1 hypertension, and 3). examine
if exercise-related differences and changes in neural integrity and cognition are mediated
by systemic vascular health.

Inclusion Criteria:

- Sedentary adults Participants will be classified as sedentary if they have not
engaged in regular physical exercise for at least one year prior to study enrollment.

- Ages 45-65

- Normal blood pressure or Borderline or stage 1 hypertension Borderline hypertension
will be defined as systolic blood pressure between 120-139 mmHg and/or diastolic
blood pressure between 80-89 mmHg. Stage 1 hypertension will be defined as systolic
blood pressure between 140-159 mmHg and/or diastolic blood pressure between 90-99
mmHg.

Exclusion Criteria:

- Signs or symptoms of chronic heart disease

- Smoking (current or within the past 6 months)

- Peripheral artery disease (ankle-brachial index<0.9)

- Diabetes (fasting blood glucose>126 mg/L)

- Orthopedic problems that would prohibit participants from participating in exercise.

- Axis I psychiatric disorder

- Magnetic resonance contraindications

- Baseline IQ < 70

- Below chance performance on the practice items of the cognitive tasks

- Evidence of large vessel stroke on magnetic resonance imaging