Airway Pressure Release Ventilation (APRV) Versus AC/VC Conventional Ventilation

Conditions:Hospital, Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases, Other
Age Range:18 - Any
Start Date:October 2011
End Date:June 2016
Contact:Eliotte Hirshberg, MD

Use our guide to learn which trials are right for you!

Airway Pressure Release Ventilation (APRV) vs. Conventional Volume Control Mechanical Ventilation for Patients With Respiratory Failure Requiring Invasive Mechanical Ventilator Support

APRV mode of ventilation will result in an improved partial pressure of arterial
oxygenation/ fraction of inspired oxygen (P/F ratio) on day 3 of mechanical ventilation. Sub
hypotheses: APRV will be associated with a reduced amount of sedation used during the ICU
stay in patients with respiratory failure. APRV will be associated with a reduction in the
amount of vasoactive medication used for blood pressure support in patients with respiratory

This prospective un-blinded randomized trial will follow patients with respiratory failure
and ALI/ARDS who require invasive mechanical ventilation in select ICUs. Patients will be
allocated to respiratory support with either APRV mode or volume control (AC) mode of
mechanical ventilation. Qualifying patients will be randomized by permuted block
randomization within 24 hours of admission to the ICU. Identical ventilation and oxygenation
thresholds will be utilized to guide titration of each ventilator protocol. Patients will
remain on the assigned mode of ventilation until they are extubated and discharged from the

Procedures for treatment evaluation include daily monitoring of the Ventilator protocol in
each arm. Clinical coordinator and study respiratory therapist will perform 2 daily checks
of the study patients to determine compliance with the protocol and if patient meets weaning
criteria. The previously published ARDS Network continuous positive airway pressure (CPAP)
weaning protocol will be used for all patients enrolled.

Inclusion Criteria:

- Hypoxemic respiratory failure requiring mechanical ventilation for >24 hours.

Exclusion Criteria:

- Age under 18

- Severe chronic obstructive lung disease

- Patients in whom the only indication for mechanical ventilation is airway protection
from poor neurological status.
We found this trial at
5121 S Cottonwood St
Murray, Utah 84157
(801) 507-7000
Principal Investigator: Eliotte Hirshberg, MD
Intermountain Medical Center Intermountain Medical Center is one of the most technologically advanced and patient-friendly...
Murray, UT
Click here to add this to my saved trials
8th Ave & C St
Salt Lake City, Utah 84143
(801) 408-1100
LDS Hospital LDS Hospital provides clinical excellence to our community in a wide range of...
Salt Lake City, UT
Click here to add this to my saved trials