Radiation Biodosimetry in Children Undergoing Total Body Irradiation



Status:Completed
Conditions:Blood Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:2 - 21
Updated:6/23/2016
Start Date:November 2010
End Date:September 2015

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The purpose of this study is to develop fecal tests that will determine the extent of
radiation exposure in patients undergoing radiation treatment for cancer. This project will
determine whether fecal biomarkers can be used to diagnose exposure to radiation.

Patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will have
feces collected for use in the validation and refinement of new methods for rapid radiation
biodosimetry. The stool samples will be collected before, and at defined times after TBI.
Stool sampling will occur in the same manner that it does during routine patient care during
HSCT.

Inclusion Criteria:

- All races are eligible

- 2 years to 21 years old

- Must be undergoing hematopoietic stem cell transplantation (either autologous or
allogeneic) in conjunction with a conditioning regimen that includes total-body
irradiation (TBI) (single or multiple fraction).
We found this trial at
1
site
9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
(414) 266-2000
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
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mi
from
Milwaukee, WI
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