Effects of Gastric Bypass Surgery and Calcium Metabolism and the Skeleton

Obesity is a chronic illness of staggering proportions. Because weight loss through diet and
exercise is difficult to attain and maintain, there has been escalating interest in bariatric
surgery, including Roux-en-Y gastric bypass. Gastric bypass surgery results in long-term
weight loss, dramatic improvement in comorbidities such as diabetes, and decreased mortality.
Emerging evidence suggests, however, that gastric bypass may have negative effects on bone
health. Because of the serious consequences of osteoporosis and fracture, this is of great
concern. This study of the effects of gastric bypass on calcium metabolism and the skeleton
may positively impact the clinical care of gastric bypass patients by their surgeons, primary
care providers, and endocrinologists. Further, the knowledge gained may inform future
investigation into the relationships between obesity, weight loss, and bone biology.