High-dose Periop Statins for Prevention of DVT



Status:Completed
Conditions:Cervical Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/2/2016
Start Date:November 2005
End Date:August 2007

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High-dose Statin Therapy in the Perioperative Period and DVT Prevention.

This study is designed to determine if the use of atorvastatin (Lipitor), a member of the
HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory
responses and deep vein thrombosis formation when given in high doses in the perioperative
period.


Inclusion Criteria:

- gynecologic tumor scheduled for resection

Exclusion Criteria:

- prior reaction to statins

- renal insufficiency

- liver disease

- h/o alcoholism

- prior h/o DVT or hypercoagulability

- concurrent medications that significantly affect cytochrome P450 3A4

- breast feeding or pregnancy
We found this trial at
1
site
20 York St, N20 York St,
New Haven, Connecticut 06520
(203) 688-4242
Yale-New Haven Hospital Relying on the skill and expertise of more than 4,500 university and...
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mi
from
New Haven, CT
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