Genetic Polymorphisms in Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic pulmonary fibrosis is one of a collection of severe lung diseases that lead to
abnormal inflammation and scarring of the lungs. The accumulation of scar tissue in the lung
destroys normal lung tissue and results in the symptoms associated with this disease. The
cause of the disease is currently unknown. In this study, we are attempting to determine if
there are specific genetic traits that might explain why patients have developed pulmonary
fibrosis. We are also attempting to determine if specific genetic traits account for
differing patterns of inflammation and scar tissue that has formed in the patient's lungs.
The purpose of this research is to identify genes that control the processes of lung
inflammation, lung scarring, and lung repair. As more information becomes available, we will
also conduct studies of additional genes that are found to be involved in this disease
process.

Inclusion Criteria:

- 18 years of age or older

- Diagnosis of pulmonary fibrosis confirmed by physical examination, pulmonary function
testing, chest X-ray, and computed tomography (CT) scans.

- Adult patients who are seeking treatment at the Dorothy P. and Richard P. Simmons
Center for Interstitial Lung Disease.

Exclusion Criteria:

- Under 18 years of age

- Non-fibrotic ILD