IL-2 "SELECT" Tissue Collection Protocol in Patients With Advanced Melanoma

Status:Active, not recruiting
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Age Range:18 - Any
Start Date:February 2010
End Date:February 2020

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The High-Dose Aldesleukin (IL-2) "SELECT" Trial: A Prospective Tissue Collection Protocol to Investigate Predictive Models of Response to High-Dose IL-2 Treatments in Patients With Advance Melanoma

The purpose of this study is to determine which participants with melanoma have a better
response to IL-2 and to identify markers that may predict response to IL-2 by collecting
participant information (for example; cancer diagnosis and history, prior treatments for
cancer, etc.) blood and tumor samples prior to treatment and tumor measurements after

Original tumor slides will be collected to identify tumor markers that may predict responses
to treatment. Blood samples will be obtained prior to treatment with IL-2.

Inclusion Criteria:

- Malignant melanoma that is metastatic or unresectable

- Eligible to receive high-dose IL-2

- Tissue block available with adequate tumor to perform RNA extraction and DASL analysis

Exclusion Criteria:

- Prior immunotherapy for unresectable or metastatic disease

- Untreated brain metastases, leptomeningeal disease, or seizure disorder
We found this trial at
330 Brookline Ave
Boston, Massachusetts 02215
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
Boston, MA
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