A Research Study Looking at Specific Tissue of the Umbilical Cord

Status:	Recruiting
Conditions:	Cardiology
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	18 - Any
Updated:	4/21/2016
Start Date:	June 2010
End Date:	June 2016
Contact:	Omar Aljitawi, MD
Email:	oaljitawi@kumc.edu
Phone:	913-588-6030

Decellularization of Umbilical Cord Wharton's Jelly for Tissue Regenerative Applications Including Avascular Necrosis

The purpose of this study is to isolate Umbilical cord Wharton's jelly matrix to be used as
a scaffold for tissue regenerative applications, including avascular necrosis.

Our working hypothesis is that umbilical cord blood Wharton's Jelly matrix has all the
biochemical and biomechanical characteristics needed in an ideal scaffold for tissue
engineering. Accordingly, we expect matrix to support the growth and differentiation of
transplanted mesenchymal stem cells. The first step in this effort is to isolate Wharton's
Jelly matrix by decellularization. The second step will be to test the ability of this
matrix to support the growth and differentiation of transplanted mesenchymal stem cells. The
third step will be to pursue preliminary animal testing to study the ability of this matrix
to support bone tissue regeneration in vivo.

Inclusion Criteria:

- Pregnant Women

- 18 years of age or older

- willing to donate umbilical cord units

Exclusion Criteria:

- less than 18 years of age

- Has Hepatitis or HIV

- Considered High Risk

- Scheduled for C-Section due to complications during current pregnancy

- Delivered prior to Full Term

We found this trial at

sites

University of Kansas Medical Center

3901 Rainbow Blvd
Kansas City, Kansas 66160

(913) 588-5000