Fish Oil and Green Tea Extract in Preventing Prostate Cancer in Patients Who Are at Risk for Developing Prostate Cancer



Status:Archived
Conditions:Prostate Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011

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Catechins and Omega-3 Fatty Acids Impact on Fatty Acid Synthase Activity in the Prostate: A Randomized Controlled Trial


RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing,
or coming back. The use of fish oil and/or green tea may prevent prostate cancer.

PURPOSE: This randomized clinical trial is studying how well a fish oil and/or green tea
supplement works in preventing prostate cancer in patients with prostatic intraepithelial
neoplasia or who are at risk for developing prostate cancer.


OBJECTIVES:

- Determine the cancer preventing effects of fish oil supplementation and green tea
extract use on markers of alteration in lipid metabolism in prostate tissue samples.

OUTLINE: This is a randomized, double-blind, placebo-controlled study. Patients are
stratified according to age (under 65 vs 65 and over). Patients are randomized to 1 of 4
treatment arms.

- Arm I: Patients receive oral fish oil three times daily and oral green tea extract
twice daily.

- Arm II: Patients receive an oil placebo three times daily and oral green tea extract
twice daily.

- Arm III: Patients receive oral fish oil three times daily and a placebo twice daily.

- Arm IV: Patients receive an oil placebo three times daily and another placebo twice
daily.

Treatment in one of the above-listed arms continues for up to 20 weeks in the absence of
disease progression or unacceptable toxicity.

All patients undergo a prostate biopsy on the last day of study treatment.

After completion of study treatment, patients receive a follow-up phone call at/around 30
days later.

PROJECTED ACCRUAL: A total of 144 patients will be accrued for this study.


We found this trial at
3
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1201 Broad Rock Boulevard
Richmond, Virginia 23249
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3181 SW Sam Jackson Park Rd
Portland, Oregon 97239
(503) 494-5058
Knight Cancer Institute at Oregon Health and Science University Cancer takes many forms. Although cancer...
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, Colorado
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