The Genetic Basis for Vulnerability to Substance Abuse

Dopamine (DA), a neurotransmitter helping to mediate reward and reinforcement, has been
putatively linked to the development of substance abuse, alcohol abuse, and alcoholism.
Identification of specific vulnerability-association alleles for receptors, other molecules
within the reward mediating system, and other genes that may predispose individuals to the
development of such disorders is the goal of the study.

This investigation will help elucidate the genetic underpinnings of substance abuse,
potentially leading to the improved methods to diagnose those at risk and to help develop
better therapeutic interventions.

Inclusion Criteria:

- Substance abusers

- Allow for blood draw

Exclusion Criteria:

- Cognitively impaired