Veliparib and Radiation Therapy in Treating Patients With Advanced Solid Malignancies With Peritoneal Carcinomatosis, Epithelial Ovarian, Fallopian, or Primary Peritoneal Cancer

PRIMARY OBJECTIVES:

I. Determine the maximum tolerable dose of veliparib in combination with low-dose
fractionated whole abdominal radiation therapy (LDFWAR) in patients with peritoneal
carcinomatosis from advanced solid malignancies. At dose levels 5 and 6: to determine the
maximum tolerable dose of veliparib in combination with LDFWAR in patients with epithelial
ovarian, fallopian or primary peritoneal cancers with intraabdominal disease.

II. Determine the safety and toxicity of the combination of veliparib in conjunction with
LDFWAR in patients with peritoneal carcinomatosis from advanced solid malignancies; at dose
levels 5 and 6: to determine the safety and toxicity of veliparib in combination with LDFWAR
in patients with epithelial ovarian, fallopian or primary peritoneal cancers with
intraabdominal disease.

SECONDARY OBJECTIVES:

I. Assess clinical activity of veliparib plus LDFWAR in patients with peritoneal
carcinomatosis from advanced solid malignancies as assessed by response rate by Response
Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. At dose levels 5 and 6: to assess
the clinical activity of veliparib plus LDFWAR in patients with epithelial ovarian, fallopian
or primary peritoneal cancer and intraabdominal disease as assessed by response rate by
RECIST 1.1 criteria.

II. Evaluate if microsatellite instability or baseline levels of various deoxyribonucleic
acid (DNA) repair proteins (excision repair cross-complementing 1 [ERCC1], x-ray repair
complementing defective repair in Chinese hamster cells 1 [XRCC1], breast cancer 1, early
onset [BRCA1], breast cancer 2, early onset [BRCA2], poly [adenosine diphosphate
(ADP)-ribosyl]ation [PAR]) correlate with clinical activity of this regimen.

III. Evaluate changes in quality of life for patients treated with this regimen by serial
measurements using the Quality of Life Questionnaire Core-30 (QLQC-30) standardized
questionnaire.

OUTLINE: This is a dose-escalation study of veliparib.

Patients receive veliparib orally (PO) twice daily (BID) on days 1-21 (days 5-21 of course
1). Patients undergo LDFWAR in BID on days 1 and 5 of weeks 1-3. Treatment repeats every 28
days for 3 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 2 months.

Inclusion Criteria:

- Dose levels 1-4 must have histologically proven solid malignancy that is metastatic or
unresectable with metastatic peritoneal carcinomatosis; as this entity may be
difficult to image, peritoneal disease can be documented through other modalities such
as operative notes, clinical notes/symptoms, etc as well as imaging

- Dose levels 5 and 6 will be open only to patients with recurrent or persistent primary
epithelial ovarian, fallopian or peritoneal cancers; at these dose levels, measurable
disease in the abdominal cavity must be present but peritoneal carcinomatosis is not
required for eligibility

- Patients must have failed first line standard therapy or have no acceptable standard
treatment options; for patients on dose levels 5 and 6, patients may be platinum
sensitive, platinum resistant or platinum refractory

- Ability to understand and the willingness to sign a written informed consent document

- Eastern Cooperative Oncology Group (ECOG) performance status =< 1

- Life expectancy of greater than 3 months

- Absolute neutrophil count (ANC) >= 1,500/mcL

- Platelets >= 100,000/mcL

- Total bilirubin =< 1.5 x upper limit of normal (ULN)

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
=< 2.5 x ULN

- Creatinine =< 1.5 x ULN OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients
with creatinine levels above institutional normal

- Calcium within normal limit (WNL)

- No surgery, hormonal therapy or chemotherapy within four weeks; for dose levels 5 and
6, patients receiving mitomycin C or nitrosoureas must discontinue treatment 6 weeks
prior to registration and any hormonal treatment directed at the malignant tumor must
be discontinued at least one week prior to registration; continuation of hormone
replacement therapy is permitted

- No previous abdominal radiation; if the patient has received previous pelvic radiation
there should not be any overlap between the current and previous radiation fields

- Toxicities of prior chemotherapy recovered to grade 1 or less except for stable grade
2 peripheral neuropathy

- Negative pregnancy test if premenopausal; women of child-bearing potential and men
must agree to use adequate contraception (hormonal or barrier method of birth control;
abstinence) prior to study entry and for the duration of study participation; should a
woman become pregnant or suspect she is pregnant while participating in this study,
she should inform her treating physician immediately

- Archival tumor sample collection with a tumor block is required for all enrolled
patients when available; this will not be required for patients on dose levels 5 and
6; if no block can be released per institutional policy, 10 to 20 unstained slides may
be substituted; slides should have a positive charge and a thickness of 3 to 5
microns; if the only tissue sample available is a fine needle aspirate (FNA), the
patient will still be considered eligible

- Patients with central nervous system (CNS) metastases to be stable after therapy for >
3 months and off steroid treatment prior to study enrollment

- For patients in dose levels 5 and 6, BRCA testing results, if previously performed,
should be attained; if no BRCA testing has been performed, patients may be referred to
a genetic counselor and will have detailed family history performed as part of the
screening process

Exclusion Criteria:

- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for
nitrosoureas or mitomycin C) prior to entering the study or those who have not
recovered from adverse events due to agents administered more than 4 weeks earlier

- Patients who are currently receiving any other investigational agents

- Brain metastases: patients with treated and stable brain metastasis for 3 months, off
steroids will be eligible

- Patients who demonstrate any clinical evidence of bleeding

- Patients who have demonstrated an inability to swallow oral medications

- Patients who currently have an active gastrointestinal obstruction, have had a
gastrointestinal obstruction within the last 30 days prior to enrollment and/or are
actively requiring parenteral nutrition are excluded; patients who have had a history
of any prior gastrointestinal obstruction requiring surgical intervention are also
excluded

- Patients who have a known hypersensitivity to the components of the study drug, its
analogs or drugs of a similar chemical or biologic composition

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnant women are excluded from this study; breastfeeding should be discontinued if
the mother is treated with veliparib

- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral
therapy are ineligible

- Patients who have uncontrolled ascites

- Patients with active seizures or a history of seizure are not eligible

- Patients previously treated with poly (ADP-ribose) polymerase 1 (PARP) inhibitors