Prospective Evaluation of Symptom Resolution in Acid Versus Non-acid Reflux Disease Following Anti-reflux Surgery

Conditions:Gastroesophageal Reflux Disease , Gastrointestinal
Therapuetic Areas:Gastroenterology
Age Range:17 - Any
Start Date:November 2010
Contact:Ellie Mentler, MD

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Prospective Evaluation of Symptom Resolution in Acid Versus Non-acid Reflux Disease Following Anti-reflux Surgery.

Gastroesophageal reflux disease (GERD) is a common ailment affecting a significant portion
of the US population. With the advent and increased use of esophageal impedance monitoring,
both acid and nonacid reflux disease can be better diagnosed and treated. Patients with
severe symptoms or symptoms refractory to medical management may be offered anti-reflux
surgery for optimal treatment. Though there are a handful of studies evaluating the efficacy
of anti-reflux surgery on those patients with acid or non-acid related reflux disease, the
comparison between acid and non-acid reflux disease following surgery is lacking. We propose
a prospective study comparing clinical outcomes from those patients with acid versus
non-acid reflux disease following anti-reflux surgery with the use of validated and disease
specific quality of life surveys.

Inclusion Criteria:

- Patients who are offered anti-reflux surgical treatment with elevated DeMeester
scores or with low (less than 14.7) DeMeester scores, but with positive impedance
scores (positive symptom index associated with reflux episodes).

Exclusion Criteria:

- • Previous major upper gastrointestinal surgery (includes esophagus, stomach, and
duodenum) - previous cholecystectomy (gallbladder removal) is not considered a major
upper GI surgery

- Presence of paraesophageal hernia (type II - type IV)

- Presence of large hiatal hernia >5cm

- Presence of peptic strictures

- History of severe esophageal motility disorders such as:

- achalasia

- diffuse esophageal spasms

- scleroderma

- poorly-controlled diabetes mellitus

- autonomic or peripheral neuropathy

- myopathy

- Pregnancy (As a standard operating procedure, women of child-bearing age will
undergo a urine pregnancy test the morning of surgery because anti-reflux
surgery is considered an elective case, where pregnancy is a relative

- BMI greater than 40

- Undergoes Collis gastroplasty during surgery

- Conversion to an open procedure

- Age less than 18 years old
We found this trial at
620 John Paul Jones Cir
Portsmouth, Virginia 23708
(757) 953-5008
Naval Medical Center - Portsmouth Naval Medical Center Portsmouth, Virginia has proudly served the military...
Portsmouth, VA
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