Efficacy of Topical Capsaicin Cream for Stable Angina
| Status: | Recruiting |
|---|---|
| Conditions: | Angina |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | October 2010 |
| Contact: | Cindy Werner, RN, BSN |
| Email: | cindy.werner@uc.edu |
| Phone: | 513-558-1331 |
A Randomized, Placebo-Controlled, Cross-Over Study to Assess the Safety and Efficacy of TOPical CAPsaicin With Stable Angina (TOPCAP)
The purpose of this study is to test the hypothesis that application of topical capsaicin in
patients with stable angina will result in improved exercise tolerance and reduced cardiac
ischemia.
Inclusion Criteria:
- > or = 3 month history of chronic, stable, angina triggered by physical effort or
mental/emotional stress
- documented stress-induced ST depression, reversible perfusion imaging, or wall motion
abnormality or CAD >50%
- Canadian CV Class I-III
- Receiving medical therapy for > or = 2 months
- Ability to perform Bruce Protocol treadmill test
- non-pregnant female
Exclusion Criteria:
- unstable angina
- revasc within 2 months
- MI within 2 months
- CHF hospitalization within 2 months
- NYHA class III or IV
- LVEF < 25%
- abnormal ECG; Acute changes on ECG
- Currently receiving treatment with investigational drugs/devices
- Uncontrolled hypertension
- contraindication to exercise stress testing
- allergy to red peppers or capsaicin
- skin deformity, scar, or rash at application site
- abdominal surgery within 3 months
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