Vitamin D Supplementation for Treatment of Heart Failure



Status:Recruiting
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:2/7/2015
Start Date:October 2010
Contact:Barry E Bleske, Pharm. D
Email:bbleske@umich.edu
Phone:734-764-5341

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D suppLementation In HearT FaiLure (DELIGHTFUL)

The central objective of this proposal is to establish that vitamin D supplementation in
heart failure patients with low vitamin D levels will have improved outcomes compared to
placebo. In addition the investigators will also evaluate the role of genetics in regard to
vitamin D and heart failure. The investigators will be evaluating what is currently a novel
approach of identifying patients with low vitamin D and treating this low vitamin D level.
The investigators will be able to evaluate the importance of vitamin D supplementation in
these patients and the role of genetics on our defined outcomes.


Inclusion Criteria:

- HF patients with LV systolic dysfunction of ischemic or non-ischemic origin and an
LVEF <40% using nuclear ventriculography or echocardiography within the last 6
months.

- Attempts should have been made at optimizing medical therapy and the participant
should be stable on these medications for at least 3 months.

- Patients with a 25(OH)D level between 10-25 ng/ml

Exclusion Criteria:

- Inability to give informed consent

- Patients with sarcoidosis or other granulomatous disease that can alter vitamin D
metabolism

- Patients with primary valvular HF, hypertrophic cardiomyopathy, and drug-induced HF

- Renal dysfunction defined as serum creatinine > 2.5 mg/dl

- Pregnant women

- Patients <18 years of age

- Patients on vitamin D supplementation
We found this trial at
1
site
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health System The University of Michigan is home to one of the...
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Ann Arbor, MI
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