Primary Care Internet-Based Depression Prevention for Adolescents (CATCH-IT)



Status:Not yet recruiting
Conditions:Anxiety, Depression, Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:Any
Updated:11/18/2012
Start Date:June 2011
End Date:June 2016
Contact:Benjamin Van Voorhees, MD
Email:bvanvoor@medicine.bsd.uchicago.edu
Phone:(773) 702-3835

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In this 5-year, two-site randomized clinical trial, we propose to test the efficacy of the
CATCH-IT primary care/Internet based depression prevention intervention against Attention
Monitoring Psychoeducation (AMPE) in preventing the onset of depressive episodes in an
intermediate to high risk group of adolescents aged 13-17. We plan to (a) identify high risk
adolescents based on elevated scores on the PHQ-A, a screening measure of depressive
symptoms; (b) recruit 400 (200 per site) of these at-risk adolescents to be randomized into
either the CATCH-IT or the AMPE group; (c) assess outcomes at 2, 8, 12, 18, and 24 months
post intake on measures of depressive symptoms, depressive diagnoses, other mental
disorders, and on measures of role impairment in education, quality of life, attainment of
educational milestones, and family functioning; and (d) conduct exploratory analyses to
examine the effectiveness of this intervention program, moderators of protection, and
potential ethnic and cultural differences in intervention response.


Inclusion Criteria:

- Youth ages 13 through 17.

- Youth must be experiencing elevated level of depressive symptoms on the Center for
Epidemiologic Studies Depression46 (CES-D) scale (score >/= 16) and have at least two
core symptoms of Major Depression on the Patient Health Questionnaire, Adolescents.

- Youth will be included if they have a past history of depression, anxiety,
externalizing symptoms, or substance abuse.

Exclusion Criteria:

- Current DSM-IV diagnosis (Kiddie Schedule of Affective Disorders) of Major Depressive
Disorder, current therapy for depression, or be taking antidepressants (e.g., SSRIs,
TCAs, MAOIs, bupropion, nefazodone, mirtazapine, venlafaxine).

- Current CES-D score >35

- DSM-IV diagnosis of schizophrenia (current or past) or bipolar affective disorder

- Current serious medical illness that causes significant disability or dysfunction

- Significant reading impairment (a minimum sixth-grade reading level based on parental
report), mental retardation, or developmental disabilities

- Serious imminent suicidal risk (as determined by endorsement of current suicidality
on CES-D or in KSADS interview) or other conditions that may require immediate
psychiatric hospitalization

- Psychotic features or disorders, or currently be receiving psychotropic medication

- Extreme, current drug/alcohol abuse (greater than or equal to 2 on the CRAFFT).
We found this trial at
4
sites
Boston, Massachusetts
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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Evanston, Illinois 60201
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Evanston, IL
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