Pilot Program to Improve Statin Adherence and Lower Cholesterol in Older Adults



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:60 - Any
Updated:4/21/2016
Start Date:October 2010
End Date:February 2014

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The purpose of this study is to pilot test a behavioral medication adherence (MA)
intervention compared to control condition in older adults with low adherence to medication
for hypercholesterolemia.

This study will answer the following primary research question:

1. What is the estimated effect size of a behavioral MA intervention on MA rates in older
adults who are poorly adherent to statin medications?

The study will also explore the following secondary research questions:

2. What is the estimated effect size of a behavioral MA intervention on low-density
lipoprotein cholesterol (LDL-C) levels in older adults?

3. What is the estimated effect size of a behavioral MA intervention on high-density
lipoprotein cholesterol (HDL-C) levels in older adults?

4. What is the feasibility of successfully testing this intervention protocol in a
population of older adults with low adherence to statin medications?


Inclusion Criteria:

- Age 60 or older at the time of study entry,

- Take a once-daily prescription statin medication for ≥ 6 months with no changes to
statin prescription for at least 30 days prior to study entry,

- A score of ≤ 9 on the Short Blessed Test,

- Participants must self-administer his or her own medications without prompts from any
other person or device.

- Baseline medication adherence rate of ≤ 90%.

- Participants agree to complete all study contacts and measurements, including the use
of a special medication bottle with a Medication Event Monitoring System (MEMS) cap
for the duration of the study.

- Able to open and close MEMS caps.

Exclusion Criteria:

- Participant's medications are managed by someone other than the participant

- Participant is unable or unwilling to use MEMS caps.
We found this trial at
1
site
Columbia, Missouri 65211
(573) 882-2121
University of Missouri T he University of Missouri was founded in 1839 in Columbia, Mo.,...
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from
Columbia, MO
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