Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury (TBI)



Status:Archived
Conditions:Depression, Neurology
Therapuetic Areas:Neurology, Psychiatry / Psychology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:September 1996
End Date:September 2012

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Trial Summary
Trial Overview
Inclusion Criteria

Prevention of Depression and Enhancement of Cognitive Recovery Following Traumatic Brain Injury With Duloxetine


The primary objective of the study is to compare the efficacy of duloxetine 60 mg PO daily
with placebo in the prevention of depression associated with mild/moderate traumatic brain
injury (TBI) and to enhance cognitive function. Research exploring the use of selective
serotonin reuptake inhibitors (SSRIs) in the treatment of post-traumatic depression
generally validates this approach (Horsfield et al., 2002). However, the literature suggests
that serotonin/norepinephrine reuptake inhibitors (SNRIs) such as duloxetine may be more
effective in the treatment of depression.



We found this trial at
1
site
Rehabilitation Hospital of Indiana
Indianapolis, Indiana 46254
?
mi
from
Indianapolis, IN
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