Polarization Sensitive Retinal Tomography for Glaucoma Diagnosis
| Status: | Archived |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | August 2007 |
| End Date: | June 2011 |
The proposed human clinical studies have three main objectives:
1. To determine reproducibility of peripapillary birefringence maps and identify features
that measure the health of the RNFL.
2. To determine the normal variation in the birefringence maps with age.
3. To develop and test a classifier for glaucoma based on the birefringence maps using a
case-control clinical trial.
This study is a case-control study intended to optimize feature selection for a future
multi-center blinded study. The proposed clinical study does not measure conversion from
normal to glaucoma.
This study evaluates RNFL Birefringence in normal and glaucoma human subjects: The primate
experimental glaucoma study will characterize the spatial and temporal dynamics of RNFL
birefringence during glaucoma progression and establish an initial feature set and
classifier for a case-control clinical study. The case-control clinical study will refine
the initial feature set and classifier and use ROC analysis to test sensitivity and
specificity of the feature set and classifier for discriminating between normal and
glaucomatous human eyes. The feature set and classifier formulated in the case-control
clinical study is a prerequisite for planning a large-scale longitudinal study. A
large-scale longitudinal study to compare different approaches for detecting early glaucoma
is outside the scope of the proposed research. Moreover, considering the large number of
subjects required for statistical significance when the conversion rate from ocular
hypertensive to glaucoma is low (<10%/year), a longitudinal study is best performed in a
multi-institution clinical trial over several years.
We found this trial at
1
site
Click here to add this to my saved trials
