L-Tyrosine Supplementation in Patients With Fibromyalgia
| Status: | Archived |
|---|---|
| Conditions: | Fibromyalgia, Pain |
| Therapuetic Areas: | Musculoskeletal, Rheumatology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | January 2010 |
| End Date: | January 2011 |
Patients in the study, who have a diagnosis of fibromyalgia, will be randomly assigned to
take the amino acid L-tyrosine or placebo (blank pill) for 3 weeks. They will fill out
questionnaires about their symptoms and see if they have any improvement. The investigators
hypothesis is that taking tyrosine will help alleviate the symptoms of fibromyalgia.
Fibromyalgia is a chronic pain syndrome with few treatment options available. The
amino-acid L-tyrosine is the precursor for norepinephrine in the central nervous system
(CNS). Norepinephrine in the CNS has important roles in pain and mood modulation and
descending inhibition of pain pathways. By giving the precursor L-tyrosine in high doses we
believe that we can increase levels of norepinephrine in the CNS. To study this question we
designed a randomized blinded pilot study of 30 patients. Patients are randomly assigned to
one of 3 groups (placebo, tyrosine 1000mg/day, and tyrosine 2000mg/day.) for 3 weeks.
Patients then complete the Brief Pain Inventory (BPI) daily and the Fibromyalgia impact
questionnaire (FIQ) on day 1 and day 21. Patients also complete a drug diary. They are
monitored weekly for progress during the study.
We found this trial at
1
site
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
Click here to add this to my saved trials
