Metformin in Castration-Resistant Prostate Cancer



Status:Archived
Conditions:Prostate Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:September 2010

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Prospective Study of Metformin in Castration-Resistant Prostate Cancer


Metformin is a medication that is prescribed for people with diabetes to help the body
respond better to its own insulin and decrease sugar production by the liver. This helps
control the body's blood sugar level and is approved by the FDA for the treatment of
diabetes. Participant's in this research study will already be receiving androgen
deprivation therapy (ADT) for prostate cancer. ADT is considered standard of care for
prostate cancer. Changes in the participant's metabolism, including changes in insulin and
blood sugar levels, are often seen as a result of this type of hormone therapy. Some
studies have shown a relationship between insulin and prostate cancer. These studies have
suggested that insulin may signal tumor cells to grow. Other studies suggest that people
receiving metformin treatment for diabetes may enjoy better outcomes from their prostate
cancer then other similar patients who are not treated with metformin.


- Each treatment cycle lasts 4 weeks (28 days). Participants will take metformin twice a
day for all 28 days (except for the first 7 days of the first cycle when they will take
it just once daily.)

- The following procedures will be done on Day 1 of treatment cycles 1, 2, 4, 7 and 10:
medical history review, performance status, physical exam, blood tests.

- If the participant's first CT or bone scan at the time of screening showed evidence of
cancer, CT and bone scans will be repeated on Day 1 of treatment cycles 4, 7 and 10.

- Participants will be in this research study for about 12 months.


We found this trial at
3
sites
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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