Heart Rate Changes During Normal Activity, Exercise, and Seizures in Subjects With Epilepsy
| Status: | Archived |
|---|---|
| Conditions: | Neurology, Epilepsy |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | September 2010 |
| End Date: | December 2010 |
The purpose of this study is to determine whether ictal tachycardia can be distinguished
from exercise-induced tachycardias using ECG signal features. Patients will be admitted to
the Epilepsy Monitoring Unit (EMU) for three days of inpatient study testing and different
exercises regime will be conducted. After 3 days, the patient may continue passive testing
(EEG, ECG, EOG, etc) for the remainder of the EMU stay.
To determine whether ictal tachycardia can be distinguished from exercise-induced
tachycardias using ECG signal features, patients will be admitted to the Epilepsy Monitoring
Unit (EMU) for three days of inpatient heart rate testing. During the EMU stay, each patient
will undergo the following testing two times each day (i.e., morning and evening):
- Record resting baseline heart rate
- Valsalva Maneuver
- Non-strenuous Activities (supine, standing, walking in place)
- Treadmill Exercise (Modified Balke Protocol used as a sub maximal test)
- Stair Stepping Exercise (YMCA 3-Minute Step Test Protocol)
After 3 days, the patient may continue passive testing (EEG, ECG, EOG, etc) for the
remainder of the EMU stay. Antiepileptic medications will be stopped upon admission to the
EMU according to local standard practice and as specified by the admitting principal
investigator. Antiepileptic medications will be restarted prior to scheduled discharge from
the EMU, based upon standard practice and the investigator's clinical judgment.
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