Hemofiltration in Burns: RESCUE (Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure)



Status:Active, not recruiting
Conditions:Other Indications, Renal Impairment / Chronic Kidney Disease, Hospital, Hematology
Therapuetic Areas:Hematology, Nephrology / Urology, Other
Healthy:No
Age Range:18 - Any
Updated:4/17/2018
Start Date:August 2011
End Date:September 2018

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The American Burn Association's Randomized Controlled Evaluation of Hemofiltration in Adult Burn Patients With Septic Shock and Acute Renal Failure

The purpose of this study is determine if High-Volume Hemofiltration in addition to
'contemporary' care will result in an improvement of select clinical outcomes when compared
to 'contemporary' care alone in the treatment of critically ill patients with ARF secondary
to septic shock.

Acute renal failure (ARF) is a common and devastating complication in critically ill burn
patients with mortality reported to be between 80 and 100%.(3-7) Despite recent advances in
burn care, the unacceptably high mortality rate in this subgroup has not changed over time.
The pathogenesis of ARF in burns, similar to other critically ill populations, is often
multi-factorial with one major component being sepsis induced ischemic tubular necrosis.
Thus, ARF secondary to septic shock is a common and devastating condition in the burn ICU.

Inclusion Criteria:

- All adult patients admitted to the burn intensive care unit (ICU) with burns of any
size

- Acute renal failure as previously defined by the Veterans Affairs/ National Institutes
of Health (VA/NIH) Acute Renal Failure Trial Network study investigators(2)

- Patient is > 48 hours post-burn and in Septic Shock

- Patients 18 or older

- Patient/legally authorized representative willing to provide consent

Exclusion Criteria:

- Age <18

- Non-thermal injury (exfoliating skin disorders or necrotizing fasciitis)

- Pre-admission diagnosis of end stage renal failure

- Patients already on renal replacement therapy for more than 24 hours

- Patient not expected to survive more than 24 hours after randomization.

- Pregnancy

- Prisoners
We found this trial at
9
sites
Kansas City, Kansas 66160
Principal Investigator: James Howard, MD
Phone: 913-588-6265
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1 Tampa General Cir
Tampa, Florida 33606
(813) 844-7000
Principal Investigator: David Smith, MD
Phone: 813-259-0924
Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
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Augusta, Georgia 30909
Principal Investigator: Amy Sprague, MD
Phone: 706-364-2966
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Augusta, GA
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Dallas, Texas 75235
Principal Investigator: Brett Arnoldo, MD
Phone: 214-648-5430
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Dallas, TX
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Fort Sam Houston, Texas 78234
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Fort Sam Houston, TX
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2160 South 1st Avenue
Maywood, Illinois 60153
(888) 584-7888
Principal Investigator: Richard L Gamelli, MD
Phone: 708-327-2072
Loyola University Medical Center Loyola University Health System is committed to excellence in patient care...
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Memphis, Tennessee 38105
Phone: 901-448-2579
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Memphis, TN
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Phoenix, Arizona 85008
Principal Investigator: Daniel M Caruso, MD
Phone: 602-344-5624
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Washington, District of Columbia 20010
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Washington,
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