Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 3/3/2019 |
| Start Date: | December 2010 |
| End Date: | June 2014 |
Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass(CPB) in Cardiac Surgery: a Randomized, Controlled Trial
This is an investigator initiated, sponsored, open label, prospective randomized controlled
trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will
be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that
occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary
bypass (CPB).
trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will
be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that
occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary
bypass (CPB).
Inclusion Criteria:
- adult patients scheduled for cardiac surgery at LLUMC University Hospital will be
eligible for participation in this study.
Exclusion Criteria:
1. severe LV (left ventricle)dysfunction (EF < 35%).
2. emergency procedures.
3. procedures with combined carotid artery surgery.
4. patients at high risk for stroke.
5. hemodynamically significant dysrhythmias.
6. pre-existing atrial fibrillation or high degree AV (atrioventricular block).
7. pacemaker dependency.
8. known sensitivity to beta blockers.
9. patient refusal.
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Loma Linda University Loma Linda University (LLU) is a Seventh-day Adventist educational health-sciences institution with...
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