Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS)
| Status: | Archived |
|---|---|
| Conditions: | Infectious Disease, Neurology |
| Therapuetic Areas: | Immunology / Infectious Diseases, Neurology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | September 2010 |
| End Date: | February 2013 |
High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab
The purpose of this study is to look at the effect of 2 different corticosteroid treatment
schedules in the setting of Immune Reconstitution Inflammatory Syndrome (IRIS) in patients
who have developed Progressive Multifocal Leukoencephalpathy (PML) while on treatment with
natalizumab.
The purpose of this study is to evaluate the effect of 2 treatment regimens, in patients who
have developed Progressive Multifocal Leukoencephalpathy (PML) while on natalizumab
treatment. These regimens are consistent with the current use and dosage of corticosteroids
in the setting of Immune Reconstitution Inflammatory Syndrome (IRIS). The main assessment
criteria is change in clinical status (as measured by Karnofsky Performance Status Scale)
over approximately 6 months. Both treatment assume that natalizumab has been removed to the
extent possible by plasma exchange and therefore, the trafficking of immune cells to the CNS
has been restored.
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